STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NBPF20Neuroblastoma breakpoint family member 20; NBPF member 20; Belongs to the NBPF family. (5207 aa)    
Predicted Functional Partners:
NOTCH2NLB
Notch homolog 2 N-terminal-like protein B; Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway. Able to promote neural progenitor self-renewal, possibly by down-regulating neuronal differentiation genes, thereby delaying the differentiation of neuronal progenitors and leading to an overall final increase in neuronal production. Acts by enhancing the Notch signaling pathway via two different mechanisms that probably work in parallel to reach the same effect. Enhances Notch signal [...]
      
 0.507
CLLU1OS
Putative chronic lymphocytic leukemia up-regulated protein 1 opposite strand transcript protein.
      
 0.473
FAM47A
Protein FAM47A; Family with sequence similarity 47 member A.
    
 
 0.449
PPIAL4C
Peptidyl-prolyl cis-trans isomerase A-like 4C; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.
    
 
 0.449
ZNF431
Zinc finger protein 431; Sequence-specific DNA binding transcriptional repressor. Represses target gene transcription by recruiting HDAC1 and HDAC2 histone deacetylases. Acts as a specific transcriptional repressor for PTCH1 during embryonic development. Required for osteoblast differentiation and sonic hedgehog/SHH signaling response. Binds to the consensus site 5'-GCGCCC-3' in the promoter of PTCH1 (By similarity). Belongs to the krueppel C2H2-type zinc-finger protein family.
    
 
 0.445
LIX1L
LIX1-like protein; Limb and CNS expressed 1 like; Belongs to the LIX1 family.
      
 0.445
KRTAP4-11
Keratin associated protein 4-11.
      
 0.418
ZNF19
Zinc finger protein 19; May be involved in transcriptional regulation.
    
 
 0.408
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, human, man
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