node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CSAG1 | GAGE2A | ENSP00000359310 | ENSP00000355421 | Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1. | G antigen 2A. | 0.453 |
CSAG1 | MAGEA1 | ENSP00000359310 | ENSP00000349085 | Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1. | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | 0.820 |
CSAG1 | MAGEA12 | ENSP00000359310 | ENSP00000377447 | Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1. | Melanoma-associated antigen 12; Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines. | 0.999 |
CSAG1 | MAGEA2 | ENSP00000359310 | ENSP00000485541 | Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1. | MAGE family member A2. | 0.868 |
CSAG1 | MAGEA3 | ENSP00000359310 | ENSP00000473093 | Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1. | Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | 0.980 |
CSAG1 | MAGEA6 | ENSP00000359310 | ENSP00000480637 | Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1. | Melanoma-associated antigen 6; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. | 0.925 |
CSAG1 | PRAME | ENSP00000359310 | ENSP00000445675 | Putative chondrosarcoma-associated gene 1 protein; Chondrosarcoma associated gene 1. | Melanoma antigen preferentially expressed in tumors; Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. | 0.526 |
CTAG1B | CTAG2 | ENSP00000332602 | ENSP00000247306 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | 0.868 |
CTAG1B | MAGEA1 | ENSP00000332602 | ENSP00000349085 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | 0.910 |
CTAG1B | MAGEA12 | ENSP00000332602 | ENSP00000377447 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 12; Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines. | 0.767 |
CTAG1B | MAGEA2 | ENSP00000332602 | ENSP00000485541 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | MAGE family member A2. | 0.828 |
CTAG1B | MAGEA3 | ENSP00000332602 | ENSP00000473093 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | 0.974 |
CTAG1B | MAGEA6 | ENSP00000332602 | ENSP00000480637 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 6; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. | 0.864 |
CTAG1B | PRAME | ENSP00000332602 | ENSP00000445675 | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | Melanoma antigen preferentially expressed in tumors; Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis. | 0.752 |
CTAG2 | CTAG1B | ENSP00000247306 | ENSP00000332602 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | Cancer/testis antigen 1B; Belongs to the CTAG/PCC1 family. | 0.868 |
CTAG2 | GAGE2A | ENSP00000247306 | ENSP00000355421 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | G antigen 2A. | 0.538 |
CTAG2 | MAGEA1 | ENSP00000247306 | ENSP00000349085 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 1; May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | 0.845 |
CTAG2 | MAGEA12 | ENSP00000247306 | ENSP00000377447 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 12; Not known, though may play a role tumor transformation or progression. In vitro promotes cell viability in melanoma cell lines. | 0.692 |
CTAG2 | MAGEA2 | ENSP00000247306 | ENSP00000485541 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | MAGE family member A2. | 0.794 |
CTAG2 | MAGEA3 | ENSP00000247306 | ENSP00000473093 | Cancer/testis antigen 2; Belongs to the CTAG/PCC1 family. | Melanoma-associated antigen 3; Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. | 0.897 |