node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DPY30 | DYDC1 | ENSP00000345837 | ENSP00000361278 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. Belongs to the dpy-30 family. | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | 0.714 |
DPY30 | DYDC2 | ENSP00000345837 | ENSP00000361272 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. Belongs to the dpy-30 family. | DPY30 domain containing 2; Belongs to the dpy-30 family. | 0.702 |
DPY30 | SETD1A | ENSP00000345837 | ENSP00000262519 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. Belongs to the dpy-30 family. | Histone-lysine N-methyltransferase SETD1A; Histone methyltransferase that specifically methylates 'Lys- 4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. | 0.999 |
DPY30 | WDR5 | ENSP00000345837 | ENSP00000351446 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. Belongs to the dpy-30 family. | WD repeat-containing protein 5; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltr [...] | 0.999 |
DPY30 | WDR5B | ENSP00000345837 | ENSP00000330381 | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. Belongs to the dpy-30 family. | WD repeat-containing protein 5B; May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex; Belongs to the WD repeat WDR5/wds family. | 0.766 |
DYDC1 | DPY30 | ENSP00000361278 | ENSP00000345837 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. Belongs to the dpy-30 family. | 0.714 |
DYDC1 | DYDC2 | ENSP00000361278 | ENSP00000361272 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | DPY30 domain containing 2; Belongs to the dpy-30 family. | 0.712 |
DYDC1 | LRRC43 | ENSP00000361278 | ENSP00000344233 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | Leucine-rich repeat-containing protein 43; Leucine rich repeat containing 43. | 0.578 |
DYDC1 | NME5 | ENSP00000361278 | ENSP00000265191 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | Nucleoside diphosphate kinase homolog 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity). | 0.805 |
DYDC1 | SETD1A | ENSP00000361278 | ENSP00000262519 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | Histone-lysine N-methyltransferase SETD1A; Histone methyltransferase that specifically methylates 'Lys- 4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. | 0.572 |
DYDC1 | SH2D4B | ENSP00000361278 | ENSP00000345295 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | SH2 domain containing 4B. | 0.686 |
DYDC1 | SH3GL3 | ENSP00000361278 | ENSP00000320092 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | Endophilin-A3; Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). | 0.585 |
DYDC1 | TSPAN14 | ENSP00000361278 | ENSP00000361231 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | Tetraspanin-14; Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity). | 0.643 |
DYDC1 | WDR5 | ENSP00000361278 | ENSP00000351446 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | WD repeat-containing protein 5; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity). In association with RBBP5 and ASH2L, stimulates the histone methyltr [...] | 0.577 |
DYDC1 | WDR5B | ENSP00000361278 | ENSP00000330381 | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | WD repeat-containing protein 5B; May function as a substrate receptor for CUL4-DDB1 ubiquitin E3 ligase complex; Belongs to the WD repeat WDR5/wds family. | 0.577 |
DYDC2 | DPY30 | ENSP00000361272 | ENSP00000345837 | DPY30 domain containing 2; Belongs to the dpy-30 family. | Protein dpy-30 homolog; As part of the MLL1/MLL complex, involved in the methylation of histone H3 at 'Lys-4', particularly trimethylation. Histone H3 'Lys- 4' methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci. May also play an indirect or direct role in endosomal transport. Belongs to the dpy-30 family. | 0.702 |
DYDC2 | DYDC1 | ENSP00000361272 | ENSP00000361278 | DPY30 domain containing 2; Belongs to the dpy-30 family. | DPY30 domain-containing protein 1; Plays a crucial role during acrosome biogenesis. | 0.712 |
DYDC2 | NME5 | ENSP00000361272 | ENSP00000265191 | DPY30 domain containing 2; Belongs to the dpy-30 family. | Nucleoside diphosphate kinase homolog 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity). | 0.886 |
DYDC2 | SETD1A | ENSP00000361272 | ENSP00000262519 | DPY30 domain containing 2; Belongs to the dpy-30 family. | Histone-lysine N-methyltransferase SETD1A; Histone methyltransferase that specifically methylates 'Lys- 4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. The non-overlapping localization with SETD1B suggests that SETD1A and SETD1B make non-redundant contributions to the epigenetic control of chromatin structure and gene expression. | 0.572 |
DYDC2 | SH2D4B | ENSP00000361272 | ENSP00000345295 | DPY30 domain containing 2; Belongs to the dpy-30 family. | SH2 domain containing 4B. | 0.646 |