node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FHIT | ZFP37 | ENSP00000418582 | ENSP00000452552 | Bis(5'-adenosyl)-triphosphatase; Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosi [...] | Zinc finger protein 37 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.665 |
LMO2 | PBX1 | ENSP00000257818 | ENSP00000405890 | Rhombotin-2; Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state. | Pre-B-cell leukemia transcription factor 1; Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhanc [...] | 0.457 |
LMO2 | ZFP37 | ENSP00000257818 | ENSP00000452552 | Rhombotin-2; Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state. | Zinc finger protein 37 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.498 |
PBX1 | LMO2 | ENSP00000405890 | ENSP00000257818 | Pre-B-cell leukemia transcription factor 1; Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhanc [...] | Rhombotin-2; Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state. | 0.457 |
PBX1 | ZFP37 | ENSP00000405890 | ENSP00000452552 | Pre-B-cell leukemia transcription factor 1; Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhanc [...] | Zinc finger protein 37 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.451 |
SF3B4 | ZFP37 | ENSP00000271628 | ENSP00000452552 | Splicing factor 3B subunit 4; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12- dependent spliceosome, which is involved in the splicing of rare clas [...] | Zinc finger protein 37 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.548 |
SLC31A2 | ZFP37 | ENSP00000259392 | ENSP00000452552 | Probable low affinity copper uptake protein 2; Involved in low-affinity copper uptake. | Zinc finger protein 37 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.493 |
SLC46A2 | ZFP37 | ENSP00000363345 | ENSP00000452552 | Thymic stromal cotransporter homolog; May act as a transporter; Belongs to the major facilitator superfamily. SLC46A family. | Zinc finger protein 37 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.620 |
TAF11 | TAF9B | ENSP00000354633 | ENSP00000339917 | Transcription initiation factor TFIID subunit 11; Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively); Belongs to the TAF11 family. | Transcription initiation factor TFIID subunit 9B; Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. | 0.999 |
TAF11 | ZFP37 | ENSP00000354633 | ENSP00000452552 | Transcription initiation factor TFIID subunit 11; Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively); Belongs to the TAF11 family. | Zinc finger protein 37 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.475 |
TAF9B | TAF11 | ENSP00000339917 | ENSP00000354633 | Transcription initiation factor TFIID subunit 9B; Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. | Transcription initiation factor TFIID subunit 11; Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively); Belongs to the TAF11 family. | 0.999 |
TAF9B | ZFP37 | ENSP00000339917 | ENSP00000452552 | Transcription initiation factor TFIID subunit 9B; Essential for cell viability. TAF9 and TAF9B are involved in transcriptional activation as well as repression of distinct but overlapping sets of genes. May have a role in gene regulation associated with apoptosis. TAFs are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. | Zinc finger protein 37 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.497 |
TRIM28 | ZFP37 | ENSP00000253024 | ENSP00000452552 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 37 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.522 |
ZFP37 | FHIT | ENSP00000452552 | ENSP00000418582 | Zinc finger protein 37 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Bis(5'-adenosyl)-triphosphatase; Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosi [...] | 0.665 |
ZFP37 | LMO2 | ENSP00000452552 | ENSP00000257818 | Zinc finger protein 37 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Rhombotin-2; Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state. | 0.498 |
ZFP37 | PBX1 | ENSP00000452552 | ENSP00000405890 | Zinc finger protein 37 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Pre-B-cell leukemia transcription factor 1; Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhanc [...] | 0.451 |
ZFP37 | SF3B4 | ENSP00000452552 | ENSP00000271628 | Zinc finger protein 37 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Splicing factor 3B subunit 4; Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12- dependent spliceosome, which is involved in the splicing of rare clas [...] | 0.548 |
ZFP37 | SLC31A2 | ENSP00000452552 | ENSP00000259392 | Zinc finger protein 37 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Probable low affinity copper uptake protein 2; Involved in low-affinity copper uptake. | 0.493 |
ZFP37 | SLC46A2 | ENSP00000452552 | ENSP00000363345 | Zinc finger protein 37 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Thymic stromal cotransporter homolog; May act as a transporter; Belongs to the major facilitator superfamily. SLC46A family. | 0.620 |
ZFP37 | TAF11 | ENSP00000452552 | ENSP00000354633 | Zinc finger protein 37 homolog; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Transcription initiation factor TFIID subunit 11; Core TAFII present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively); Belongs to the TAF11 family. | 0.475 |