node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARMC1 | MTFR1L | ENSP00000276569 | ENSP00000363419 | Armadillo repeat containing 1. | Mitochondrial fission regulator 1 like; Belongs to the MTFR1 family. | 0.801 |
ARMC10 | MTFR1L | ENSP00000319412 | ENSP00000363419 | Armadillo repeat-containing protein 10; May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53. | Mitochondrial fission regulator 1 like; Belongs to the MTFR1 family. | 0.452 |
CSTF1 | MTFR1L | ENSP00000217109 | ENSP00000363419 | Cleavage stimulation factor subunit 1; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA. | Mitochondrial fission regulator 1 like; Belongs to the MTFR1 family. | 0.461 |
LAMTOR3 | MTFR1L | ENSP00000424183 | ENSP00000363419 | Ragulator complex protein LAMTOR3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP k [...] | Mitochondrial fission regulator 1 like; Belongs to the MTFR1 family. | 0.411 |
MAIP1 | MTFR1L | ENSP00000295079 | ENSP00000363419 | m-AAA protease-interacting protein 1, mitochondrial; Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB). | Mitochondrial fission regulator 1 like; Belongs to the MTFR1 family. | 0.429 |
MAVS | MTFR1L | ENSP00000401980 | ENSP00000363419 | Mitochondrial antiviral-signaling protein; Required for innate immune defense against viruses. Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that [...] | Mitochondrial fission regulator 1 like; Belongs to the MTFR1 family. | 0.411 |
MTFR1L | ARMC1 | ENSP00000363419 | ENSP00000276569 | Mitochondrial fission regulator 1 like; Belongs to the MTFR1 family. | Armadillo repeat containing 1. | 0.801 |
MTFR1L | ARMC10 | ENSP00000363419 | ENSP00000319412 | Mitochondrial fission regulator 1 like; Belongs to the MTFR1 family. | Armadillo repeat-containing protein 10; May play a role in cell survival and cell growth. May suppress the transcriptional activity of p53/TP53. | 0.452 |
MTFR1L | CSTF1 | ENSP00000363419 | ENSP00000217109 | Mitochondrial fission regulator 1 like; Belongs to the MTFR1 family. | Cleavage stimulation factor subunit 1; One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA. | 0.461 |
MTFR1L | LAMTOR3 | ENSP00000363419 | ENSP00000424183 | Mitochondrial fission regulator 1 like; Belongs to the MTFR1 family. | Ragulator complex protein LAMTOR3; As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V- ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP k [...] | 0.411 |
MTFR1L | MAIP1 | ENSP00000363419 | ENSP00000295079 | Mitochondrial fission regulator 1 like; Belongs to the MTFR1 family. | m-AAA protease-interacting protein 1, mitochondrial; Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation. Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB). | 0.429 |
MTFR1L | MAVS | ENSP00000363419 | ENSP00000401980 | Mitochondrial fission regulator 1 like; Belongs to the MTFR1 family. | Mitochondrial antiviral-signaling protein; Required for innate immune defense against viruses. Acts downstream of DHX33, DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that [...] | 0.411 |
MTFR1L | OLFM4 | ENSP00000363419 | ENSP00000219022 | Mitochondrial fission regulator 1 like; Belongs to the MTFR1 family. | Olfactomedin-4; May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin. | 0.420 |
MTFR1L | SLC12A8 | ENSP00000363419 | ENSP00000377112 | Mitochondrial fission regulator 1 like; Belongs to the MTFR1 family. | Solute carrier family 12 member 8; Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation. | 0.485 |
MTFR1L | TATDN2 | ENSP00000363419 | ENSP00000287652 | Mitochondrial fission regulator 1 like; Belongs to the MTFR1 family. | Putative deoxyribonuclease TATDN2; Putative deoxyribonuclease. | 0.570 |
MTFR1L | VPS33A | ENSP00000363419 | ENSP00000267199 | Mitochondrial fission regulator 1 like; Belongs to the MTFR1 family. | Vacuolar protein sorting-associated protein 33A; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosom [...] | 0.474 |
OLFM4 | MTFR1L | ENSP00000219022 | ENSP00000363419 | Olfactomedin-4; May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin. | Mitochondrial fission regulator 1 like; Belongs to the MTFR1 family. | 0.420 |
SLC12A8 | MTFR1L | ENSP00000377112 | ENSP00000363419 | Solute carrier family 12 member 8; Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation. | Mitochondrial fission regulator 1 like; Belongs to the MTFR1 family. | 0.485 |
SLC12A8 | TATDN2 | ENSP00000377112 | ENSP00000287652 | Solute carrier family 12 member 8; Cation/chloride cotransporter that may play a role in the control of keratinocyte proliferation. | Putative deoxyribonuclease TATDN2; Putative deoxyribonuclease. | 0.446 |
TATDN2 | MTFR1L | ENSP00000287652 | ENSP00000363419 | Putative deoxyribonuclease TATDN2; Putative deoxyribonuclease. | Mitochondrial fission regulator 1 like; Belongs to the MTFR1 family. | 0.570 |