node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B3GALT4 | PGAP4 | ENSP00000390784 | ENSP00000363984 | Beta-1,3-galactosyltransferase 4; Involved in GM1/GD1B/GA1 ganglioside biosynthesis. | Transmembrane protein 246; post-GPI attachment to proteins GalNAc transferase 4. | 0.507 |
B3GALT4 | ST3GAL5 | ENSP00000390784 | ENSP00000491316 | Beta-1,3-galactosyltransferase 4; Involved in GM1/GD1B/GA1 ganglioside biosynthesis. | Lactosylceramide alpha-2,3-sialyltransferase; Catalyzes the formation of ganglioside GM3 (alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D-glucosylceramide). | 0.646 |
FREM1 | PGAP4 | ENSP00000412940 | ENSP00000363984 | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family. | Transmembrane protein 246; post-GPI attachment to proteins GalNAc transferase 4. | 0.462 |
PGAP2 | PGAP3 | ENSP00000278243 | ENSP00000300658 | Post-GPI attachment to proteins factor 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity); Belongs to the PGAP2 family. | Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable); Belongs to the PGAP3 family. | 0.882 |
PGAP2 | PGAP4 | ENSP00000278243 | ENSP00000363984 | Post-GPI attachment to proteins factor 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity); Belongs to the PGAP2 family. | Transmembrane protein 246; post-GPI attachment to proteins GalNAc transferase 4. | 0.416 |
PGAP2 | PIGB | ENSP00000278243 | ENSP00000164305 | Post-GPI attachment to proteins factor 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity); Belongs to the PGAP2 family. | GPI mannosyltransferase 3; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2- GlcN-acyl-PI during GPI precursor assembly. Belongs to the glycosyltransferase 22 family. PIGB subfamily. | 0.605 |
PGAP2 | PIGO | ENSP00000278243 | ENSP00000367880 | Post-GPI attachment to proteins factor 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity); Belongs to the PGAP2 family. | GPI ethanolamine phosphate transferase 3; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI- anchor to the C-terminus of the proteins by an amide bond. Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily. | 0.863 |
PGAP2 | PIGZ | ENSP00000278243 | ENSP00000413405 | Post-GPI attachment to proteins factor 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity); Belongs to the PGAP2 family. | GPI mannosyltransferase 4; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers a fourth mannose to some trimannosyl- GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is facultative and only scarcely detected, suggesting that it only exists in some tissues; Belongs to the glycosyltransferase 22 family. PIGZ subfamily. | 0.469 |
PGAP3 | PGAP2 | ENSP00000300658 | ENSP00000278243 | Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable); Belongs to the PGAP3 family. | Post-GPI attachment to proteins factor 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity); Belongs to the PGAP2 family. | 0.882 |
PGAP3 | PGAP4 | ENSP00000300658 | ENSP00000363984 | Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable); Belongs to the PGAP3 family. | Transmembrane protein 246; post-GPI attachment to proteins GalNAc transferase 4. | 0.448 |
PGAP3 | PIGB | ENSP00000300658 | ENSP00000164305 | Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable); Belongs to the PGAP3 family. | GPI mannosyltransferase 3; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2- GlcN-acyl-PI during GPI precursor assembly. Belongs to the glycosyltransferase 22 family. PIGB subfamily. | 0.472 |
PGAP3 | PIGO | ENSP00000300658 | ENSP00000367880 | Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable); Belongs to the PGAP3 family. | GPI ethanolamine phosphate transferase 3; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI- anchor to the C-terminus of the proteins by an amide bond. Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily. | 0.765 |
PGAP4 | B3GALT4 | ENSP00000363984 | ENSP00000390784 | Transmembrane protein 246; post-GPI attachment to proteins GalNAc transferase 4. | Beta-1,3-galactosyltransferase 4; Involved in GM1/GD1B/GA1 ganglioside biosynthesis. | 0.507 |
PGAP4 | FREM1 | ENSP00000363984 | ENSP00000412940 | Transmembrane protein 246; post-GPI attachment to proteins GalNAc transferase 4. | FRAS1-related extracellular matrix protein 1; Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development; Belongs to the FRAS1 family. | 0.462 |
PGAP4 | PGAP2 | ENSP00000363984 | ENSP00000278243 | Transmembrane protein 246; post-GPI attachment to proteins GalNAc transferase 4. | Post-GPI attachment to proteins factor 2; Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface (By similarity); Belongs to the PGAP2 family. | 0.416 |
PGAP4 | PGAP3 | ENSP00000363984 | ENSP00000300658 | Transmembrane protein 246; post-GPI attachment to proteins GalNAc transferase 4. | Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation. Lipid remodeling steps consist in the generation of 2 saturated fatty chains at the sn-2 position of GPI-anchors proteins. Required for phospholipase A2 activity that removes an acyl-chain at the sn-2 position of GPI-anchors during the remodeling of GPI (Probable); Belongs to the PGAP3 family. | 0.448 |
PGAP4 | PIGB | ENSP00000363984 | ENSP00000164305 | Transmembrane protein 246; post-GPI attachment to proteins GalNAc transferase 4. | GPI mannosyltransferase 3; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2- GlcN-acyl-PI during GPI precursor assembly. Belongs to the glycosyltransferase 22 family. PIGB subfamily. | 0.446 |
PGAP4 | PIGO | ENSP00000363984 | ENSP00000367880 | Transmembrane protein 246; post-GPI attachment to proteins GalNAc transferase 4. | GPI ethanolamine phosphate transferase 3; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI- anchor to the C-terminus of the proteins by an amide bond. Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily. | 0.541 |
PGAP4 | PIGS | ENSP00000363984 | ENSP00000309430 | Transmembrane protein 246; post-GPI attachment to proteins GalNAc transferase 4. | GPI transamidase component PIG-S; Component of the GPI transamidase complex. Essential for transfer of GPI to proteins, particularly for formation of carbonyl intermediates. | 0.417 |
PGAP4 | PIGZ | ENSP00000363984 | ENSP00000413405 | Transmembrane protein 246; post-GPI attachment to proteins GalNAc transferase 4. | GPI mannosyltransferase 4; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. Transfers a fourth mannose to some trimannosyl- GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is facultative and only scarcely detected, suggesting that it only exists in some tissues; Belongs to the glycosyltransferase 22 family. PIGZ subfamily. | 0.669 |