node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CABLES1 | CCDC180 | ENSP00000256925 | ENSP00000501085 | CDK5 and ABL1 enzyme substrate 1; Cyclin-dependent kinase binding protein. Enhances cyclin- dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). | Coiled-coil domain containing 180. | 0.589 |
CABLES1 | CDK17 | ENSP00000256925 | ENSP00000261211 | CDK5 and ABL1 enzyme substrate 1; Cyclin-dependent kinase binding protein. Enhances cyclin- dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). | Cyclin-dependent kinase 17; May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | 0.885 |
CABLES1 | TDRD7 | ENSP00000256925 | ENSP00000347444 | CDK5 and ABL1 enzyme substrate 1; Cyclin-dependent kinase binding protein. Enhances cyclin- dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). | Tudor domain-containing protein 7; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis; Belongs to the TDRD7 family. | 0.898 |
CCDC180 | CABLES1 | ENSP00000501085 | ENSP00000256925 | Coiled-coil domain containing 180. | CDK5 and ABL1 enzyme substrate 1; Cyclin-dependent kinase binding protein. Enhances cyclin- dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). | 0.589 |
CCDC180 | CDK17 | ENSP00000501085 | ENSP00000261211 | Coiled-coil domain containing 180. | Cyclin-dependent kinase 17; May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | 0.829 |
CCDC180 | CFAP221 | ENSP00000501085 | ENSP00000393222 | Coiled-coil domain containing 180. | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis. | 0.621 |
CCDC180 | CPVL | ENSP00000501085 | ENSP00000387164 | Coiled-coil domain containing 180. | Probable serine carboxypeptidase CPVL; May be involved in the digestion of phagocytosed particles in the lysosome, participation in an inflammatory protease cascade, and trimming of peptides for antigen presentation; Belongs to the peptidase S10 family. | 0.604 |
CCDC180 | KIAA1257 | ENSP00000501085 | ENSP00000265068 | Coiled-coil domain containing 180. | Uncharacterized protein KIAA1257. | 0.717 |
CCDC180 | LRGUK | ENSP00000501085 | ENSP00000285928 | Coiled-coil domain containing 180. | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. | 0.635 |
CCDC180 | SPAG17 | ENSP00000501085 | ENSP00000337804 | Coiled-coil domain containing 180. | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts. | 0.609 |
CCDC180 | SPATA17 | ENSP00000501085 | ENSP00000355900 | Coiled-coil domain containing 180. | Spermatogenesis-associated protein 17; Spermatogenesis associated 17. | 0.682 |
CCDC180 | TDRD7 | ENSP00000501085 | ENSP00000347444 | Coiled-coil domain containing 180. | Tudor domain-containing protein 7; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis; Belongs to the TDRD7 family. | 0.926 |
CCDC180 | UBAC2 | ENSP00000501085 | ENSP00000383911 | Coiled-coil domain containing 180. | Ubiquitin-associated domain-containing protein 2; Restricts trafficking of FAF2 from the endoplasmic reticulum to lipid droplets. In association with LMBR1L and E3 ubiquitin-protein ligase AMFR, negatively regulates the canonical Wnt signaling pathway in the lymphocytes by promoting the ubiquitin- mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6. | 0.597 |
CDK17 | CABLES1 | ENSP00000261211 | ENSP00000256925 | Cyclin-dependent kinase 17; May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | CDK5 and ABL1 enzyme substrate 1; Cyclin-dependent kinase binding protein. Enhances cyclin- dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity). | 0.885 |
CDK17 | CCDC180 | ENSP00000261211 | ENSP00000501085 | Cyclin-dependent kinase 17; May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | Coiled-coil domain containing 180. | 0.829 |
CDK17 | TDRD7 | ENSP00000261211 | ENSP00000347444 | Cyclin-dependent kinase 17; May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1 (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. | Tudor domain-containing protein 7; Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis; Belongs to the TDRD7 family. | 0.953 |
CFAP221 | CCDC180 | ENSP00000393222 | ENSP00000501085 | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis. | Coiled-coil domain containing 180. | 0.621 |
CFAP221 | KIAA1257 | ENSP00000393222 | ENSP00000265068 | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis. | Uncharacterized protein KIAA1257. | 0.591 |
CFAP221 | LRGUK | ENSP00000393222 | ENSP00000285928 | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis. | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. | 0.849 |
CFAP221 | SPAG17 | ENSP00000393222 | ENSP00000337804 | Cilia- and flagella-associated protein 221; May play a role in cilium morphogenesis. | Sperm-associated antigen 17; Component of the central pair apparatus of ciliary axonemes. Plays a critical role in the function and structure of motile cilia. May play a role in endochondral bone formation, most likely because of a function in primary cilia of chondrocytes and osteoblasts. | 0.807 |