node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADPRHL1 | DCUN1D2 | ENSP00000364567 | ENSP00000417706 | [Protein ADP-ribosylarginine] hydrolase-like protein 1; ADP-ribosylhydrolase like 1. | DCN1-like protein 2; Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8-conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. | 0.633 |
ADPRHL1 | GRTP1 | ENSP00000364567 | ENSP00000364579 | [Protein ADP-ribosylarginine] hydrolase-like protein 1; ADP-ribosylhydrolase like 1. | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s). | 0.737 |
ADPRHL1 | TMCO3 | ENSP00000364567 | ENSP00000389399 | [Protein ADP-ribosylarginine] hydrolase-like protein 1; ADP-ribosylhydrolase like 1. | Transmembrane and coiled-coil domain-containing protein 3; Probable Na(+)/H(+) antiporter; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | 0.546 |
DCUN1D2 | ADPRHL1 | ENSP00000417706 | ENSP00000364567 | DCN1-like protein 2; Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8-conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. | [Protein ADP-ribosylarginine] hydrolase-like protein 1; ADP-ribosylhydrolase like 1. | 0.633 |
DCUN1D2 | GRTP1 | ENSP00000417706 | ENSP00000364579 | DCN1-like protein 2; Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8-conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s). | 0.551 |
DCUN1D2 | TMCO3 | ENSP00000417706 | ENSP00000389399 | DCN1-like protein 2; Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8-conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. | Transmembrane and coiled-coil domain-containing protein 3; Probable Na(+)/H(+) antiporter; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | 0.495 |
GRTP1 | ADPRHL1 | ENSP00000364579 | ENSP00000364567 | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s). | [Protein ADP-ribosylarginine] hydrolase-like protein 1; ADP-ribosylhydrolase like 1. | 0.737 |
GRTP1 | DCUN1D2 | ENSP00000364579 | ENSP00000417706 | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s). | DCN1-like protein 2; Potently stimulates the neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes from the NEDD8-conjugating E2 enzyme UBC12. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. | 0.551 |
GRTP1 | MYOZ3 | ENSP00000364579 | ENSP00000297130 | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s). | Myozenin-3; Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. | 0.481 |
GRTP1 | PCID2 | ENSP00000364579 | ENSP00000479494 | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s). | PCI domain-containing protein 2; Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (Probable). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells. | 0.569 |
GRTP1 | TBC1D13 | ENSP00000364579 | ENSP00000361731 | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s). | TBC1 domain family member 13; Acts as a GTPase-activating protein for RAB35. Together with RAB35 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes. | 0.474 |
GRTP1 | TBC1D20 | ENSP00000364579 | ENSP00000346139 | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s). | TBC1 domain family member 20; GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude. | 0.476 |
GRTP1 | TBC1D22A | ENSP00000364579 | ENSP00000336724 | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s). | TBC1 domain family member 22A; May act as a GTPase-activating protein for Rab family protein(s). | 0.588 |
GRTP1 | TBC1D5 | ENSP00000364579 | ENSP00000402935 | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s). | TBC1 domain family member 5; May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity. Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy. May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogrammin [...] | 0.531 |
GRTP1 | TMCO3 | ENSP00000364579 | ENSP00000389399 | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s). | Transmembrane and coiled-coil domain-containing protein 3; Probable Na(+)/H(+) antiporter; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | 0.624 |
GRTP1 | ZNF780A | ENSP00000364579 | ENSP00000400997 | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s). | Zinc finger protein 780A; May be involved in transcriptional regulation. | 0.537 |
MYOZ3 | GRTP1 | ENSP00000297130 | ENSP00000364579 | Myozenin-3; Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s). | 0.481 |
MYOZ3 | ZNF780A | ENSP00000297130 | ENSP00000400997 | Myozenin-3; Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma- filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. | Zinc finger protein 780A; May be involved in transcriptional regulation. | 0.520 |
PCID2 | GRTP1 | ENSP00000479494 | ENSP00000364579 | PCI domain-containing protein 2; Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (Probable). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells. | Growth hormone-regulated TBC protein 1; May act as a GTPase-activating protein for Rab family protein(s). | 0.569 |
PCID2 | TMCO3 | ENSP00000479494 | ENSP00000389399 | PCI domain-containing protein 2; Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (Probable). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells. | Transmembrane and coiled-coil domain-containing protein 3; Probable Na(+)/H(+) antiporter; Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family. | 0.486 |