node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CLSTN1 | LZIC | ENSP00000366513 | ENSP00000366430 | Soluble Alc-alpha; Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent tran [...] | Protein LZIC; Leucine zipper and CTNNBIP1 domain containing. | 0.516 |
DCTPP1 | LZIC | ENSP00000322524 | ENSP00000366430 | dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. | Protein LZIC; Leucine zipper and CTNNBIP1 domain containing. | 0.514 |
GPR157 | LZIC | ENSP00000366628 | ENSP00000366430 | G-protein coupled receptor 157; Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol- calcium second messenger; Belongs to the G-protein coupled receptor 2 family. | Protein LZIC; Leucine zipper and CTNNBIP1 domain containing. | 0.664 |
GPR157 | SLC25A33 | ENSP00000366628 | ENSP00000306328 | G-protein coupled receptor 157; Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol- calcium second messenger; Belongs to the G-protein coupled receptor 2 family. | Solute carrier family 25 member 33; Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and m [...] | 0.460 |
GPR157 | SLC45A1 | ENSP00000366628 | ENSP00000418096 | G-protein coupled receptor 157; Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol- calcium second messenger; Belongs to the G-protein coupled receptor 2 family. | Proton-associated sugar transporter A; Proton-associated glucose transporter in the brain. Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. | 0.419 |
KCTD9 | KTI12 | ENSP00000221200 | ENSP00000360676 | BTB/POZ domain-containing protein KCTD9; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. | KTI12 chromatin associated homolog. | 0.404 |
KCTD9 | LZIC | ENSP00000221200 | ENSP00000366430 | BTB/POZ domain-containing protein KCTD9; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. | Protein LZIC; Leucine zipper and CTNNBIP1 domain containing. | 0.487 |
KCTD9 | TMEM144 | ENSP00000221200 | ENSP00000296529 | BTB/POZ domain-containing protein KCTD9; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. | Transmembrane protein 144; Belongs to the TMEM144 family. | 0.485 |
KTI12 | KCTD9 | ENSP00000360676 | ENSP00000221200 | KTI12 chromatin associated homolog. | BTB/POZ domain-containing protein KCTD9; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. | 0.404 |
KTI12 | LZIC | ENSP00000360676 | ENSP00000366430 | KTI12 chromatin associated homolog. | Protein LZIC; Leucine zipper and CTNNBIP1 domain containing. | 0.546 |
KTI12 | TMEM144 | ENSP00000360676 | ENSP00000296529 | KTI12 chromatin associated homolog. | Transmembrane protein 144; Belongs to the TMEM144 family. | 0.537 |
LRIF1 | LZIC | ENSP00000358778 | ENSP00000366430 | Ligand-dependent nuclear receptor-interacting factor 1; Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin. Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases. | Protein LZIC; Leucine zipper and CTNNBIP1 domain containing. | 0.489 |
LZIC | CLSTN1 | ENSP00000366430 | ENSP00000366513 | Protein LZIC; Leucine zipper and CTNNBIP1 domain containing. | Soluble Alc-alpha; Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent tran [...] | 0.516 |
LZIC | DCTPP1 | ENSP00000366430 | ENSP00000322524 | Protein LZIC; Leucine zipper and CTNNBIP1 domain containing. | dCTP pyrophosphatase 1; Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism. | 0.514 |
LZIC | GPR157 | ENSP00000366430 | ENSP00000366628 | Protein LZIC; Leucine zipper and CTNNBIP1 domain containing. | G-protein coupled receptor 157; Orphan receptor that promotes neuronal differentiation of radial glial progenitors (RGPs). The activity of this receptor is mediated by a G(q)-protein that activates a phosphatidylinositol- calcium second messenger; Belongs to the G-protein coupled receptor 2 family. | 0.664 |
LZIC | KCTD9 | ENSP00000366430 | ENSP00000221200 | Protein LZIC; Leucine zipper and CTNNBIP1 domain containing. | BTB/POZ domain-containing protein KCTD9; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. | 0.487 |
LZIC | KTI12 | ENSP00000366430 | ENSP00000360676 | Protein LZIC; Leucine zipper and CTNNBIP1 domain containing. | KTI12 chromatin associated homolog. | 0.546 |
LZIC | LRIF1 | ENSP00000366430 | ENSP00000358778 | Protein LZIC; Leucine zipper and CTNNBIP1 domain containing. | Ligand-dependent nuclear receptor-interacting factor 1; Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin. Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases. | 0.489 |
LZIC | NMNAT1 | ENSP00000366430 | ENSP00000366410 | Protein LZIC; Leucine zipper and CTNNBIP1 domain containing. | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less [...] | 0.568 |
LZIC | SLC25A33 | ENSP00000366430 | ENSP00000306328 | Protein LZIC; Leucine zipper and CTNNBIP1 domain containing. | Solute carrier family 25 member 33; Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Transports preferentially uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism. Also transports guanine but not adenine (deoxy)nucleotides. Is inhibited strongly by pyridoxal 5'-phosphate, 4,7-diphenyl-1,10-phenanthroline, tannic acid, and mercurials (mercury dichloride, mersalyl acid, p-hydroxymercuribenzoate). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and m [...] | 0.537 |