node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CMTM3 | PRRG1 | ENSP00000400482 | ENSP00000444278 | CKLF like MARVEL transmembrane domain containing 3; Belongs to the chemokine-like factor family. | Transmembrane gamma-carboxyglutamic acid protein 1; Proline rich and Gla domain 1. | 0.410 |
DYNLT3 | LANCL3 | ENSP00000367841 | ENSP00000367882 | Dynein light chain Tctex-type 3; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity); Belongs to the dynein light chain Tctex-type family. | LanC-like protein 3; LanC like 3. | 0.487 |
DYNLT3 | PRRG1 | ENSP00000367841 | ENSP00000444278 | Dynein light chain Tctex-type 3; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity); Belongs to the dynein light chain Tctex-type family. | Transmembrane gamma-carboxyglutamic acid protein 1; Proline rich and Gla domain 1. | 0.435 |
GGCX | MGP | ENSP00000233838 | ENSP00000228938 | Vitamin K-dependent gamma-carboxylase; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. | Matrix Gla protein; Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation. | 0.951 |
GGCX | PRRG1 | ENSP00000233838 | ENSP00000444278 | Vitamin K-dependent gamma-carboxylase; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. | Transmembrane gamma-carboxyglutamic acid protein 1; Proline rich and Gla domain 1. | 0.940 |
GGCX | UCMA | ENSP00000233838 | ENSP00000367952 | Vitamin K-dependent gamma-carboxylase; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. | Unique cartilage matrix-associated protein C-terminal fragment; May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. | 0.684 |
LANCL3 | DYNLT3 | ENSP00000367882 | ENSP00000367841 | LanC-like protein 3; LanC like 3. | Dynein light chain Tctex-type 3; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity); Belongs to the dynein light chain Tctex-type family. | 0.487 |
LANCL3 | PRRG1 | ENSP00000367882 | ENSP00000444278 | LanC-like protein 3; LanC like 3. | Transmembrane gamma-carboxyglutamic acid protein 1; Proline rich and Gla domain 1. | 0.583 |
MGP | GGCX | ENSP00000228938 | ENSP00000233838 | Matrix Gla protein; Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation. | Vitamin K-dependent gamma-carboxylase; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. | 0.951 |
MGP | PRRG1 | ENSP00000228938 | ENSP00000444278 | Matrix Gla protein; Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation. | Transmembrane gamma-carboxyglutamic acid protein 1; Proline rich and Gla domain 1. | 0.479 |
MGP | UCMA | ENSP00000228938 | ENSP00000367952 | Matrix Gla protein; Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation. | Unique cartilage matrix-associated protein C-terminal fragment; May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. | 0.762 |
PRRG1 | CMTM3 | ENSP00000444278 | ENSP00000400482 | Transmembrane gamma-carboxyglutamic acid protein 1; Proline rich and Gla domain 1. | CKLF like MARVEL transmembrane domain containing 3; Belongs to the chemokine-like factor family. | 0.410 |
PRRG1 | DYNLT3 | ENSP00000444278 | ENSP00000367841 | Transmembrane gamma-carboxyglutamic acid protein 1; Proline rich and Gla domain 1. | Dynein light chain Tctex-type 3; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Probably binds BUB3 as part of transport cargo. Required for the efficient progression through mitosis (By similarity); Belongs to the dynein light chain Tctex-type family. | 0.435 |
PRRG1 | GGCX | ENSP00000444278 | ENSP00000233838 | Transmembrane gamma-carboxyglutamic acid protein 1; Proline rich and Gla domain 1. | Vitamin K-dependent gamma-carboxylase; Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. | 0.940 |
PRRG1 | LANCL3 | ENSP00000444278 | ENSP00000367882 | Transmembrane gamma-carboxyglutamic acid protein 1; Proline rich and Gla domain 1. | LanC-like protein 3; LanC like 3. | 0.583 |
PRRG1 | MGP | ENSP00000444278 | ENSP00000228938 | Transmembrane gamma-carboxyglutamic acid protein 1; Proline rich and Gla domain 1. | Matrix Gla protein; Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation. | 0.479 |
PRRG1 | RFFL | ENSP00000444278 | ENSP00000326170 | Transmembrane gamma-carboxyglutamic acid protein 1; Proline rich and Gla domain 1. | E3 ubiquitin-protein ligase rififylin; E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regulates the tumor ne [...] | 0.432 |
PRRG1 | SLC44A1 | ENSP00000444278 | ENSP00000363852 | Transmembrane gamma-carboxyglutamic acid protein 1; Proline rich and Gla domain 1. | Choline transporter-like protein 1; Choline transporter. May be involved in membrane synthesis and myelin production; Belongs to the CTL (choline transporter-like) family. | 0.422 |
PRRG1 | TMEM47 | ENSP00000444278 | ENSP00000275954 | Transmembrane gamma-carboxyglutamic acid protein 1; Proline rich and Gla domain 1. | Transmembrane protein 47; Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May regulate F-actin polymerization required for tight junctional localization dynamics and affect the junctional localization of PARD6B. During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin (By similarity); Belongs to the TMEM47 family. | 0.467 |
PRRG1 | UCMA | ENSP00000444278 | ENSP00000367952 | Transmembrane gamma-carboxyglutamic acid protein 1; Proline rich and Gla domain 1. | Unique cartilage matrix-associated protein C-terminal fragment; May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. | 0.595 |