node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AK9 | C2orf50 | ENSP00000410186 | ENSP00000370997 | Adenylate kinase 9; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has both nucleoside monophosphate and diphosphate kinase activities. Catalyzes the phosphorylation of AMP, dAMP, CMP and dCMP with ATP as phosphate donor and of CMP with GTP as phosphate donor. Also catalyzes the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and TTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor. Shows substrate preference of CDP > UDP > ADP > GDP > TDP. | Uncharacterized protein C2orf50; Chromosome 2 open reading frame 50. | 0.590 |
C1orf158 | C2orf50 | ENSP00000477802 | ENSP00000370997 | Uncharacterized protein C1orf158; Chromosome 1 open reading frame 158. | Uncharacterized protein C2orf50; Chromosome 2 open reading frame 50. | 0.454 |
C1orf158 | CDC20B | ENSP00000477802 | ENSP00000370781 | Uncharacterized protein C1orf158; Chromosome 1 open reading frame 158. | Cell division cycle 20B; Belongs to the WD repeat CDC20/Fizzy family. | 0.935 |
C2orf50 | AK9 | ENSP00000370997 | ENSP00000410186 | Uncharacterized protein C2orf50; Chromosome 2 open reading frame 50. | Adenylate kinase 9; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has both nucleoside monophosphate and diphosphate kinase activities. Catalyzes the phosphorylation of AMP, dAMP, CMP and dCMP with ATP as phosphate donor and of CMP with GTP as phosphate donor. Also catalyzes the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and TTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donor. Shows substrate preference of CDP > UDP > ADP > GDP > TDP. | 0.590 |
C2orf50 | C1orf158 | ENSP00000370997 | ENSP00000477802 | Uncharacterized protein C2orf50; Chromosome 2 open reading frame 50. | Uncharacterized protein C1orf158; Chromosome 1 open reading frame 158. | 0.454 |
C2orf50 | CDC20B | ENSP00000370997 | ENSP00000370781 | Uncharacterized protein C2orf50; Chromosome 2 open reading frame 50. | Cell division cycle 20B; Belongs to the WD repeat CDC20/Fizzy family. | 0.483 |
C2orf50 | FAM126A | ENSP00000370997 | ENSP00000403396 | Uncharacterized protein C2orf50; Chromosome 2 open reading frame 50. | Hyccin; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P. Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system. May also have a role in the beta- catenin/Lef signaling pathway (Probable). | 0.475 |
C2orf50 | GSTA4 | ENSP00000370997 | ENSP00000360002 | Uncharacterized protein C2orf50; Chromosome 2 open reading frame 50. | Glutathione S-transferase A4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4- hydroxynonenal (4-HNE). | 0.546 |
C2orf50 | PI4KA | ENSP00000370997 | ENSP00000255882 | Uncharacterized protein C2orf50; Chromosome 2 open reading frame 50. | Phosphatidylinositol 4-kinase alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. | 0.420 |
C2orf50 | PTPN18 | ENSP00000370997 | ENSP00000175756 | Uncharacterized protein C2orf50; Chromosome 2 open reading frame 50. | Tyrosine-protein phosphatase non-receptor type 18; Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues. | 0.507 |
C2orf50 | SNAPC4 | ENSP00000370997 | ENSP00000298532 | Uncharacterized protein C2orf50; Chromosome 2 open reading frame 50. | snRNA-activating protein complex subunit 4; Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. | 0.583 |
C2orf50 | TTC7B | ENSP00000370997 | ENSP00000336127 | Uncharacterized protein C2orf50; Chromosome 2 open reading frame 50. | Tetratricopeptide repeat protein 7B; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and FAM126A, via direct interactions. | 0.593 |
C2orf50 | USP36 | ENSP00000370997 | ENSP00000441214 | Uncharacterized protein C2orf50; Chromosome 2 open reading frame 50. | Ubiquitin carboxyl-terminal hydrolase 36; Deubiquitinase essential for the regulation of nucleolar structure and function. Required for cell and organism viability. Plays an important role in ribosomal RNA processing and protein synthesis, which is mediated, at least in part, through deubiquitination of DHX33, NPM1 and FBL, regulating their protein stability. Functions as a transcriptional repressor by deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, such as CDKN1A, thereby preventing histone H3 'Lys-4' trimethylation (H3K4). Specifically deubiq [...] | 0.431 |
CDC20B | C1orf158 | ENSP00000370781 | ENSP00000477802 | Cell division cycle 20B; Belongs to the WD repeat CDC20/Fizzy family. | Uncharacterized protein C1orf158; Chromosome 1 open reading frame 158. | 0.935 |
CDC20B | C2orf50 | ENSP00000370781 | ENSP00000370997 | Cell division cycle 20B; Belongs to the WD repeat CDC20/Fizzy family. | Uncharacterized protein C2orf50; Chromosome 2 open reading frame 50. | 0.483 |
FAM126A | C2orf50 | ENSP00000403396 | ENSP00000370997 | Hyccin; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P. Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system. May also have a role in the beta- catenin/Lef signaling pathway (Probable). | Uncharacterized protein C2orf50; Chromosome 2 open reading frame 50. | 0.475 |
FAM126A | PI4KA | ENSP00000403396 | ENSP00000255882 | Hyccin; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P. Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system. May also have a role in the beta- catenin/Lef signaling pathway (Probable). | Phosphatidylinositol 4-kinase alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. | 0.959 |
FAM126A | TTC7B | ENSP00000403396 | ENSP00000336127 | Hyccin; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P. Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system. May also have a role in the beta- catenin/Lef signaling pathway (Probable). | Tetratricopeptide repeat protein 7B; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and FAM126A, via direct interactions. | 0.995 |
GSTA4 | C2orf50 | ENSP00000360002 | ENSP00000370997 | Glutathione S-transferase A4; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. This isozyme has a high catalytic efficiency with 4-hydroxyalkenals such as 4- hydroxynonenal (4-HNE). | Uncharacterized protein C2orf50; Chromosome 2 open reading frame 50. | 0.546 |
PI4KA | C2orf50 | ENSP00000255882 | ENSP00000370997 | Phosphatidylinositol 4-kinase alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. | Uncharacterized protein C2orf50; Chromosome 2 open reading frame 50. | 0.420 |