node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANKAR | C17orf67 | ENSP00000427882 | ENSP00000380959 | Ankyrin and armadillo repeat containing. | Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67. | 0.457 |
ANKFN1 | C17orf67 | ENSP00000321627 | ENSP00000380959 | Ankyrin repeat and fibronectin type III domain containing 1. | Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67. | 0.561 |
ANKFN1 | SYNGR2 | ENSP00000321627 | ENSP00000467600 | Ankyrin repeat and fibronectin type III domain containing 1. | Synaptogyrin-2; May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane; Belongs to the synaptogyrin family. | 0.470 |
BSPH1 | C17orf67 | ENSP00000341762 | ENSP00000380959 | Binder of sperm protein homolog 1; Binds sperm in vitro and promotes sperm capacitation. Specifically promotes capacitation induced by high density lipoproteins (HDLs). Also binds heparin, phospholipid liposomes, and weakly to gelatin. Does not bind chondroitin sulfate B. | Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67. | 0.571 |
C17orf67 | ANKAR | ENSP00000380959 | ENSP00000427882 | Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67. | Ankyrin and armadillo repeat containing. | 0.457 |
C17orf67 | ANKFN1 | ENSP00000380959 | ENSP00000321627 | Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67. | Ankyrin repeat and fibronectin type III domain containing 1. | 0.561 |
C17orf67 | BSPH1 | ENSP00000380959 | ENSP00000341762 | Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67. | Binder of sperm protein homolog 1; Binds sperm in vitro and promotes sperm capacitation. Specifically promotes capacitation induced by high density lipoproteins (HDLs). Also binds heparin, phospholipid liposomes, and weakly to gelatin. Does not bind chondroitin sulfate B. | 0.571 |
C17orf67 | DGKE | ENSP00000380959 | ENSP00000284061 | Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67. | Diacylglycerol kinase epsilon; Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition. | 0.546 |
C17orf67 | DOT1L | ENSP00000380959 | ENSP00000381657 | Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67. | Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. | 0.460 |
C17orf67 | FAM180A | ENSP00000380959 | ENSP00000342336 | Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67. | Protein FAM180A; Family with sequence similarity 180 member A. | 0.437 |
C17orf67 | ILRUN | ENSP00000380959 | ENSP00000363135 | Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67. | Protein ILRUN; Negative regulator of innate antiviral response. Blocks IRF3- dependent cytokine production such as IFNA, IFNB and TNF. Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP. | 0.446 |
C17orf67 | RFLNA | ENSP00000380959 | ENSP00000374377 | Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67. | Refilin-A; Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in actin cytoskeleton formation in developing cartilaginous cells. | 0.462 |
C17orf67 | RUFY1 | ENSP00000380959 | ENSP00000325594 | Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67. | RUN and FYVE domain-containing protein 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking. | 0.489 |
C17orf67 | SYNGR2 | ENSP00000380959 | ENSP00000467600 | Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67. | Synaptogyrin-2; May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane; Belongs to the synaptogyrin family. | 0.435 |
DGKE | C17orf67 | ENSP00000284061 | ENSP00000380959 | Diacylglycerol kinase epsilon; Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition. | Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67. | 0.546 |
DOT1L | C17orf67 | ENSP00000381657 | ENSP00000380959 | Histone-lysine N-methyltransferase, H3 lysine-79 specific; Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA. | Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67. | 0.460 |
FAM180A | C17orf67 | ENSP00000342336 | ENSP00000380959 | Protein FAM180A; Family with sequence similarity 180 member A. | Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67. | 0.437 |
ILRUN | C17orf67 | ENSP00000363135 | ENSP00000380959 | Protein ILRUN; Negative regulator of innate antiviral response. Blocks IRF3- dependent cytokine production such as IFNA, IFNB and TNF. Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP. | Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67. | 0.446 |
RFLNA | C17orf67 | ENSP00000374377 | ENSP00000380959 | Refilin-A; Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in actin cytoskeleton formation in developing cartilaginous cells. | Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67. | 0.462 |
RUFY1 | C17orf67 | ENSP00000325594 | ENSP00000380959 | RUN and FYVE domain-containing protein 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking. | Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67. | 0.489 |