node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRD1 | BRPF3 | ENSP00000410042 | ENSP00000350267 | Bromodomain-containing protein 1; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. | Bromodomain and PHD finger-containing protein 3; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. | 0.987 |
BRD1 | HIC2 | ENSP00000410042 | ENSP00000387757 | Bromodomain-containing protein 1; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. | Hypermethylated in cancer 2 protein; Transcriptional repressor. | 0.442 |
BRPF3 | BRD1 | ENSP00000350267 | ENSP00000410042 | Bromodomain and PHD finger-containing protein 3; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. | Bromodomain-containing protein 1; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. | 0.987 |
BRPF3 | HIC2 | ENSP00000350267 | ENSP00000387757 | Bromodomain and PHD finger-containing protein 3; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. | Hypermethylated in cancer 2 protein; Transcriptional repressor. | 0.432 |
CCDC61 | FNDC4 | ENSP00000471454 | ENSP00000264703 | Coiled-coil domain containing 61. | Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis. | 0.547 |
CCDC61 | HIC2 | ENSP00000471454 | ENSP00000387757 | Coiled-coil domain containing 61. | Hypermethylated in cancer 2 protein; Transcriptional repressor. | 0.541 |
CCDC61 | PNPO | ENSP00000471454 | ENSP00000493302 | Coiled-coil domain containing 61. | Pyridoxine-5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). | 0.476 |
CTBP1 | CTBP2 | ENSP00000290921 | ENSP00000311825 | C-terminal-binding protein 1; Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | C-terminal-binding protein 2; Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.999 |
CTBP1 | HIC2 | ENSP00000290921 | ENSP00000387757 | C-terminal-binding protein 1; Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Hypermethylated in cancer 2 protein; Transcriptional repressor. | 0.864 |
CTBP2 | CTBP1 | ENSP00000311825 | ENSP00000290921 | C-terminal-binding protein 2; Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | C-terminal-binding protein 1; Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.999 |
CTBP2 | HIC2 | ENSP00000311825 | ENSP00000387757 | C-terminal-binding protein 2; Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | Hypermethylated in cancer 2 protein; Transcriptional repressor. | 0.775 |
FNDC4 | CCDC61 | ENSP00000264703 | ENSP00000471454 | Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis. | Coiled-coil domain containing 61. | 0.547 |
FNDC4 | HIC2 | ENSP00000264703 | ENSP00000387757 | Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis. | Hypermethylated in cancer 2 protein; Transcriptional repressor. | 0.462 |
FNDC4 | PNPO | ENSP00000264703 | ENSP00000493302 | Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis. | Pyridoxine-5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). | 0.428 |
HIC2 | BRD1 | ENSP00000387757 | ENSP00000410042 | Hypermethylated in cancer 2 protein; Transcriptional repressor. | Bromodomain-containing protein 1; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. | 0.442 |
HIC2 | BRPF3 | ENSP00000387757 | ENSP00000350267 | Hypermethylated in cancer 2 protein; Transcriptional repressor. | Bromodomain and PHD finger-containing protein 3; Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. | 0.432 |
HIC2 | CCDC61 | ENSP00000387757 | ENSP00000471454 | Hypermethylated in cancer 2 protein; Transcriptional repressor. | Coiled-coil domain containing 61. | 0.541 |
HIC2 | CTBP1 | ENSP00000387757 | ENSP00000290921 | Hypermethylated in cancer 2 protein; Transcriptional repressor. | C-terminal-binding protein 1; Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.864 |
HIC2 | CTBP2 | ENSP00000387757 | ENSP00000311825 | Hypermethylated in cancer 2 protein; Transcriptional repressor. | C-terminal-binding protein 2; Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.775 |
HIC2 | FNDC4 | ENSP00000387757 | ENSP00000264703 | Hypermethylated in cancer 2 protein; Transcriptional repressor. | Fibronectin type III domain-containing protein 4; Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro- inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis. | 0.462 |