node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCDC36 | KBTBD12 | ENSP00000391788 | ENSP00000385957 | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance. | Kelch repeat and BTB domain containing 12. | 0.533 |
CCDC36 | PRR35 | ENSP00000391788 | ENSP00000386499 | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance. | Proline-rich protein 35; Proline rich 35. | 0.599 |
CCDC36 | RRP36 | ENSP00000391788 | ENSP00000244496 | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance. | Ribosomal RNA processing protein 36 homolog; Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA. Belongs to the RRP36 family. | 0.506 |
CCDC36 | TOGARAM1 | ENSP00000391788 | ENSP00000354917 | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance. | TOG array regulator of axonemal microtubules protein 1; Required for normal structure and function of primary cilia. Plays a role in the organization of axoneme microtubule bundles in primary cilia (By similarity). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (By similarity). Belongs to the Crescerin family. | 0.476 |
CCDC36 | TRAPPC6B | ENSP00000391788 | ENSP00000330289 | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance. | Trafficking protein particle complex subunit 6B; Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic. Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival (Probable). | 0.471 |
CCDC36 | VWC2 | ENSP00000391788 | ENSP00000341819 | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance. | Brorin; BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity). | 0.452 |
KBTBD12 | CCDC36 | ENSP00000385957 | ENSP00000391788 | Kelch repeat and BTB domain containing 12. | Interactor of HORMAD1 protein 1; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance. | 0.533 |
KBTBD12 | KLHDC8B | ENSP00000385957 | ENSP00000327468 | Kelch repeat and BTB domain containing 12. | Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. | 0.583 |
KBTBD12 | PRR35 | ENSP00000385957 | ENSP00000386499 | Kelch repeat and BTB domain containing 12. | Proline-rich protein 35; Proline rich 35. | 0.676 |
KBTBD12 | RRP36 | ENSP00000385957 | ENSP00000244496 | Kelch repeat and BTB domain containing 12. | Ribosomal RNA processing protein 36 homolog; Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA. Belongs to the RRP36 family. | 0.589 |
KBTBD12 | SPATA48 | ENSP00000385957 | ENSP00000297001 | Kelch repeat and BTB domain containing 12. | Spermatogenesis-associated protein 48; Spermatogenesis associated 48. | 0.554 |
KBTBD12 | TAFA2 | ENSP00000385957 | ENSP00000393987 | Kelch repeat and BTB domain containing 12. | Chemokine-like protein TAFA-2; Has a role as neurotrophic factor involved in neuronal survival and neurobiological functions; Belongs to the TAFA family. | 0.544 |
KBTBD12 | TMEM161B | ENSP00000385957 | ENSP00000426354 | Kelch repeat and BTB domain containing 12. | Transmembrane protein 161B; Belongs to the TMEM161 family. | 0.560 |
KBTBD12 | TOGARAM1 | ENSP00000385957 | ENSP00000354917 | Kelch repeat and BTB domain containing 12. | TOG array regulator of axonemal microtubules protein 1; Required for normal structure and function of primary cilia. Plays a role in the organization of axoneme microtubule bundles in primary cilia (By similarity). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (By similarity). Belongs to the Crescerin family. | 0.557 |
KBTBD12 | TRAPPC6B | ENSP00000385957 | ENSP00000330289 | Kelch repeat and BTB domain containing 12. | Trafficking protein particle complex subunit 6B; Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic. Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival (Probable). | 0.539 |
KBTBD12 | VWC2 | ENSP00000385957 | ENSP00000341819 | Kelch repeat and BTB domain containing 12. | Brorin; BMP antagonist which may play a role in neural development. Promotes cell adhesion (By similarity). | 0.531 |
KLHDC8B | KBTBD12 | ENSP00000327468 | ENSP00000385957 | Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. | Kelch repeat and BTB domain containing 12. | 0.583 |
KLHDC8B | PRR35 | ENSP00000327468 | ENSP00000386499 | Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. | Proline-rich protein 35; Proline rich 35. | 0.596 |
KLHDC8B | RRP36 | ENSP00000327468 | ENSP00000244496 | Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. | Ribosomal RNA processing protein 36 homolog; Involved in the early processing steps of the pre-rRNA in the maturation pathway leading to the 18S rRNA. Belongs to the RRP36 family. | 0.532 |
KLHDC8B | SPATA48 | ENSP00000327468 | ENSP00000297001 | Kelch domain-containing protein 8B; Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. | Spermatogenesis-associated protein 48; Spermatogenesis associated 48. | 0.516 |