node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCNE1 | PPP1R1C | ENSP00000262643 | ENSP00000280295 | G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition. | Protein phosphatase 1 regulatory subunit 1C; May increase cell susceptibility to TNF-induced apoptosis. | 0.608 |
DPH6 | HYDIN | ENSP00000256538 | ENSP00000377197 | Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity). | Hydrocephalus-inducing protein homolog; Required for ciliary motility. | 0.413 |
DPH6 | MYO3B | ENSP00000256538 | ENSP00000386213 | Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity). | Myosin-IIIb; Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments. | 0.413 |
DPH6 | PPP1R1C | ENSP00000256538 | ENSP00000280295 | Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity). | Protein phosphatase 1 regulatory subunit 1C; May increase cell susceptibility to TNF-induced apoptosis. | 0.460 |
HYDIN | DPH6 | ENSP00000377197 | ENSP00000256538 | Hydrocephalus-inducing protein homolog; Required for ciliary motility. | Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity). | 0.413 |
HYDIN | PPP1R1C | ENSP00000377197 | ENSP00000280295 | Hydrocephalus-inducing protein homolog; Required for ciliary motility. | Protein phosphatase 1 regulatory subunit 1C; May increase cell susceptibility to TNF-induced apoptosis. | 0.414 |
MGAT4C | PPP1R1C | ENSP00000481096 | ENSP00000280295 | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C; Glycosyltransferase that participates in the transfer of N- acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity). | Protein phosphatase 1 regulatory subunit 1C; May increase cell susceptibility to TNF-induced apoptosis. | 0.409 |
MYO3B | DPH6 | ENSP00000386213 | ENSP00000256538 | Myosin-IIIb; Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments. | Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity). | 0.413 |
MYO3B | PPP1R1C | ENSP00000386213 | ENSP00000280295 | Myosin-IIIb; Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments. | Protein phosphatase 1 regulatory subunit 1C; May increase cell susceptibility to TNF-induced apoptosis. | 0.403 |
PPP1CA | PPP1R1C | ENSP00000326031 | ENSP00000280295 | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin de [...] | Protein phosphatase 1 regulatory subunit 1C; May increase cell susceptibility to TNF-induced apoptosis. | 0.701 |
PPP1R1C | CCNE1 | ENSP00000280295 | ENSP00000262643 | Protein phosphatase 1 regulatory subunit 1C; May increase cell susceptibility to TNF-induced apoptosis. | G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition. | 0.608 |
PPP1R1C | DPH6 | ENSP00000280295 | ENSP00000256538 | Protein phosphatase 1 regulatory subunit 1C; May increase cell susceptibility to TNF-induced apoptosis. | Diphthine--ammonia ligase; Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. Diphthamide biosynthesis consists in the conversion of an L-histidine residue in the translation elongation factor (EEF2) to diphthamide (By similarity). | 0.460 |
PPP1R1C | HYDIN | ENSP00000280295 | ENSP00000377197 | Protein phosphatase 1 regulatory subunit 1C; May increase cell susceptibility to TNF-induced apoptosis. | Hydrocephalus-inducing protein homolog; Required for ciliary motility. | 0.414 |
PPP1R1C | MGAT4C | ENSP00000280295 | ENSP00000481096 | Protein phosphatase 1 regulatory subunit 1C; May increase cell susceptibility to TNF-induced apoptosis. | Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C; Glycosyltransferase that participates in the transfer of N- acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity). | 0.409 |
PPP1R1C | MYO3B | ENSP00000280295 | ENSP00000386213 | Protein phosphatase 1 regulatory subunit 1C; May increase cell susceptibility to TNF-induced apoptosis. | Myosin-IIIb; Probable actin-based motor with a protein kinase activity. Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern. Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments. | 0.403 |
PPP1R1C | PPP1CA | ENSP00000280295 | ENSP00000326031 | Protein phosphatase 1 regulatory subunit 1C; May increase cell susceptibility to TNF-induced apoptosis. | Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin de [...] | 0.701 |