node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHST7 | LACTBL1 | ENSP00000276055 | ENSP00000402297 | Carbohydrate sulfotransferase 7; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4 [...] | Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family. | 0.561 |
KLHL24 | LACTBL1 | ENSP00000395012 | ENSP00000402297 | Kelch-like protein 24; Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation. Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity). | Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family. | 0.499 |
LACTBL1 | CHST7 | ENSP00000402297 | ENSP00000276055 | Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family. | Carbohydrate sulfotransferase 7; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4 [...] | 0.561 |
LACTBL1 | KLHL24 | ENSP00000402297 | ENSP00000395012 | Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family. | Kelch-like protein 24; Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation. Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (By similarity). | 0.499 |
LACTBL1 | LEMD3 | ENSP00000402297 | ENSP00000308369 | Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family. | Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. | 0.437 |
LACTBL1 | NME5 | ENSP00000402297 | ENSP00000265191 | Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family. | Nucleoside diphosphate kinase homolog 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity). | 0.462 |
LACTBL1 | PLA2G4D | ENSP00000402297 | ENSP00000290472 | Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family. | Cytosolic phospholipase A2 delta; Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has a preference for linoleic acid at the sn-2 position. | 0.418 |
LACTBL1 | PLA2G4E | ENSP00000402297 | ENSP00000382434 | Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family. | Cytosolic phospholipase A2 epsilon; Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. | 0.415 |
LACTBL1 | RS1 | ENSP00000402297 | ENSP00000369320 | Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family. | Retinoschisin; Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides (By similarity). May play a role in cell-cell adhesion processes in the retina, via homomeric interaction between octamers present on the surface of two neighboring cells. Required for normal structure and function of the retina. | 0.514 |
LACTBL1 | SNRPB2 | ENSP00000402297 | ENSP00000246071 | Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family. | U2 small nuclear ribonucleoprotein B'; Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA. | 0.530 |
LACTBL1 | SSBP3 | ENSP00000402297 | ENSP00000360371 | Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family. | Single-stranded DNA-binding protein 3; May be involved in transcription regulation of the alpha 2(I) collagen gene where it binds to the single-stranded polypyrimidine sequences in the promoter region. | 0.432 |
LACTBL1 | TMEM154 | ENSP00000402297 | ENSP00000302144 | Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family. | Transmembrane protein 154. | 0.480 |
LEMD3 | LACTBL1 | ENSP00000308369 | ENSP00000402297 | Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest. | Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family. | 0.437 |
NME5 | LACTBL1 | ENSP00000265191 | ENSP00000402297 | Nucleoside diphosphate kinase homolog 5; Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity). | Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family. | 0.462 |
PLA2G4D | LACTBL1 | ENSP00000290472 | ENSP00000402297 | Cytosolic phospholipase A2 delta; Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has a preference for linoleic acid at the sn-2 position. | Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family. | 0.418 |
PLA2G4D | PLA2G4E | ENSP00000290472 | ENSP00000382434 | Cytosolic phospholipase A2 delta; Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has a preference for linoleic acid at the sn-2 position. | Cytosolic phospholipase A2 epsilon; Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. | 0.486 |
PLA2G4E | LACTBL1 | ENSP00000382434 | ENSP00000402297 | Cytosolic phospholipase A2 epsilon; Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. | Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family. | 0.415 |
PLA2G4E | PLA2G4D | ENSP00000382434 | ENSP00000290472 | Cytosolic phospholipase A2 epsilon; Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. | Cytosolic phospholipase A2 delta; Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has a preference for linoleic acid at the sn-2 position. | 0.486 |
RS1 | LACTBL1 | ENSP00000369320 | ENSP00000402297 | Retinoschisin; Binds negatively charged membrane lipids, such as phosphatidylserine and phosphoinositides (By similarity). May play a role in cell-cell adhesion processes in the retina, via homomeric interaction between octamers present on the surface of two neighboring cells. Required for normal structure and function of the retina. | Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family. | 0.514 |
SNRPB2 | LACTBL1 | ENSP00000246071 | ENSP00000402297 | U2 small nuclear ribonucleoprotein B'; Involved in pre-mRNA splicing as component of the spliceosome. Associated with sn-RNP U2, where it contributes to the binding of stem loop IV of U2 snRNA. | Putative beta-lactamase-like 1; Lactamase beta like 1; Belongs to the beta-lactamase family. | 0.530 |