node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C10orf99 | IGFL1 | ENSP00000361199 | ENSP00000415823 | Protein GPR15L; Chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15. May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest. | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor. | 0.534 |
DIRC1 | IGFL1 | ENSP00000307860 | ENSP00000415823 | Disrupted in renal carcinoma 1. | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor. | 0.442 |
EIF3C | IGFL1 | ENSP00000332604 | ENSP00000415823 | Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl- tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor. | 0.402 |
FAM53A | IGFL1 | ENSP00000310057 | ENSP00000415823 | Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle. Belongs to the FAM53 family. | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor. | 0.411 |
IGFL1 | C10orf99 | ENSP00000415823 | ENSP00000361199 | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor. | Protein GPR15L; Chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15. May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest. | 0.534 |
IGFL1 | DIRC1 | ENSP00000415823 | ENSP00000307860 | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor. | Disrupted in renal carcinoma 1. | 0.442 |
IGFL1 | EIF3C | ENSP00000415823 | ENSP00000332604 | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor. | Eukaryotic translation initiation factor 3 subunit C; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl- tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] | 0.402 |
IGFL1 | FAM53A | ENSP00000415823 | ENSP00000310057 | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor. | Protein FAM53A; May play an important role in neural development; the dorsomedial roof of the third ventricle. Belongs to the FAM53 family. | 0.411 |
IGFL1 | IGFLR1 | ENSP00000415823 | ENSP00000246532 | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor. | IGF-like family receptor 1; Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2. | 0.768 |
IGFL1 | KRTAP10-11 | ENSP00000415823 | ENSP00000334197 | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor. | Keratin-associated protein 10-11; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 10 family. | 0.404 |
IGFL1 | KRTAP10-3 | ENSP00000415823 | ENSP00000375478 | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor. | Keratin-associated protein 10-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. | 0.418 |
IGFL1 | KRTAP10-4 | ENSP00000415823 | ENSP00000383225 | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor. | Keratin-associated protein 10-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 10 family. | 0.418 |
IGFL1 | KRTAP10-9 | ENSP00000415823 | ENSP00000381009 | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor. | Keratin-associated protein 10-9; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. | 0.447 |
IGFL1 | NPTX2 | ENSP00000415823 | ENSP00000265634 | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor. | Neuronal pentraxin-2; Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity). | 0.429 |
IGFLR1 | IGFL1 | ENSP00000246532 | ENSP00000415823 | IGF-like family receptor 1; Probable cell membrane receptor for the IGF-like family proteins. Binds IGFL1 and IGFL3 with a higher affinity. May also bind IGFL2. | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor. | 0.768 |
KRTAP10-11 | IGFL1 | ENSP00000334197 | ENSP00000415823 | Keratin-associated protein 10-11; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 10 family. | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor. | 0.404 |
KRTAP10-11 | KRTAP10-3 | ENSP00000334197 | ENSP00000375478 | Keratin-associated protein 10-11; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 10 family. | Keratin-associated protein 10-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. | 0.661 |
KRTAP10-11 | KRTAP10-4 | ENSP00000334197 | ENSP00000383225 | Keratin-associated protein 10-11; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 10 family. | Keratin-associated protein 10-4; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 10 family. | 0.736 |
KRTAP10-11 | KRTAP10-9 | ENSP00000334197 | ENSP00000381009 | Keratin-associated protein 10-11; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins; Belongs to the KRTAP type 10 family. | Keratin-associated protein 10-9; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. | 0.869 |
KRTAP10-3 | IGFL1 | ENSP00000375478 | ENSP00000415823 | Keratin-associated protein 10-3; In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin- associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins. | Insulin growth factor-like family member 1; Probable ligand of the IGFLR1 cell membrane receptor. | 0.418 |