node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADGRL1 | C1orf210 | ENSP00000340688 | ENSP00000430918 | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity). | Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane. | 0.514 |
ADGRL2 | C1orf210 | ENSP00000359765 | ENSP00000430918 | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. | Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane. | 0.514 |
ADGRL3 | C1orf210 | ENSP00000422533 | ENSP00000430918 | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. | Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane. | 0.514 |
BTBD10 | C1orf210 | ENSP00000431186 | ENSP00000430918 | BTB/POZ domain-containing protein 10; Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells. | Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane. | 0.408 |
C1orf210 | ADGRL1 | ENSP00000430918 | ENSP00000340688 | Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane. | Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity). | 0.514 |
C1orf210 | ADGRL2 | ENSP00000430918 | ENSP00000359765 | Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane. | Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. | 0.514 |
C1orf210 | ADGRL3 | ENSP00000430918 | ENSP00000422533 | Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane. | Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. | 0.514 |
C1orf210 | BTBD10 | ENSP00000430918 | ENSP00000431186 | Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane. | BTB/POZ domain-containing protein 10; Plays a major role as an activator of AKT family members by inhibiting PPP2CA-mediated dephosphorylation, thereby keeping AKTs activated. Plays a role in preventing motor neuronal death and accelerating the growth of pancreatic beta cells. | 0.408 |
C1orf210 | FAM71E2 | ENSP00000430918 | ENSP00000398617 | Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane. | Protein FAM71E2; Family with sequence similarity 71 member E2; Belongs to the FAM71 family. | 0.611 |
C1orf210 | GPN2 | ENSP00000430918 | ENSP00000363250 | Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane. | GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. | 0.441 |
C1orf210 | KDF1 | ENSP00000430918 | ENSP00000319179 | Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane. | Keratinocyte differentiation factor 1; Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny (By similarity). | 0.467 |
C1orf210 | RIC1 | ENSP00000430918 | ENSP00000416696 | Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane. | RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1. | 0.481 |
C1orf210 | SOWAHB | ENSP00000430918 | ENSP00000334879 | Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane. | Ankyrin repeat domain-containing protein SOWAHB; Sosondowah ankyrin repeat domain family member B; Belongs to the SOWAH family. | 0.454 |
C1orf210 | WDR72 | ENSP00000430918 | ENSP00000379619 | Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane. | WD repeat-containing protein 72; Plays a major role in formation of tooth enamel. Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane. | 0.424 |
FAM71E2 | C1orf210 | ENSP00000398617 | ENSP00000430918 | Protein FAM71E2; Family with sequence similarity 71 member E2; Belongs to the FAM71 family. | Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane. | 0.611 |
GPN2 | C1orf210 | ENSP00000363250 | ENSP00000430918 | GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family. | Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane. | 0.441 |
KDF1 | C1orf210 | ENSP00000319179 | ENSP00000430918 | Keratinocyte differentiation factor 1; Plays a role in the regulation of the epidermis formation during early development. Required both as an inhibitor of basal cell proliferation and a promoter of differentiation of basal progenitor cell progeny (By similarity). | Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane. | 0.467 |
RIC1 | C1orf210 | ENSP00000416696 | ENSP00000430918 | RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1. | Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane. | 0.481 |
SOWAHB | C1orf210 | ENSP00000334879 | ENSP00000430918 | Ankyrin repeat domain-containing protein SOWAHB; Sosondowah ankyrin repeat domain family member B; Belongs to the SOWAH family. | Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane. | 0.454 |
WDR72 | C1orf210 | ENSP00000379619 | ENSP00000430918 | WD repeat-containing protein 72; Plays a major role in formation of tooth enamel. Specifically required during the maturation phase of amelogenesis for normal formation of the enamel matrix and clearance of enamel proteins. May be involved in localization of the calcium transporter SLC24A4 to the ameloblast cell membrane. | Type III endosome membrane protein TEMP; May be involved in membrane trafficking between endosomes and plasma membrane. | 0.424 |