node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FAM71D | MS4A5 | ENSP00000483154 | ENSP00000300190 | Protein FAM71D; Family with sequence similarity 71 member D. | Membrane-spanning 4-domains subfamily A member 5; May be involved in signal transduction as a component of a multimeric receptor complex. | 0.579 |
FAM71D | OR51I2 | ENSP00000483154 | ENSP00000493016 | Protein FAM71D; Family with sequence similarity 71 member D. | Olfactory receptor 51I2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | 0.559 |
FAM71D | RNF17 | ENSP00000483154 | ENSP00000255324 | Protein FAM71D; Family with sequence similarity 71 member D. | RING finger protein 17; Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity). | 0.545 |
FAM71D | ROPN1L | ENSP00000483154 | ENSP00000421405 | Protein FAM71D; Family with sequence similarity 71 member D. | Ropporin-1-like protein; Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation. | 0.564 |
FAM71D | SLC9B1 | ENSP00000483154 | ENSP00000296422 | Protein FAM71D; Family with sequence similarity 71 member D. | Sodium/hydrogen exchanger 9B1; Sperm-specific Na(+)/H(+) exchanger involved in intracellular pH regulation of spermatozoa. Involved in sperm motility and fertility. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | 0.551 |
FAM71D | SOX30 | ENSP00000483154 | ENSP00000265007 | Protein FAM71D; Family with sequence similarity 71 member D. | Transcription factor SOX-30; Acts as both a transcriptional activator and repressor. Binds to the DNA sequence 5'-ACAAT- 3' and shows a preference for guanine residues surrounding this core motif. Binds to its own promoter and activates its own transcription (By similarity). Required to activate the expression of postmeiotic genes involved in spermiogenesis (By similarity). Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling. Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with [...] | 0.529 |
FAM71D | SPATA16 | ENSP00000483154 | ENSP00000341765 | Protein FAM71D; Family with sequence similarity 71 member D. | Spermatogenesis-associated protein 16; Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion. | 0.538 |
FAM71D | SYCE3 | ENSP00000483154 | ENSP00000385480 | Protein FAM71D; Family with sequence similarity 71 member D. | Synaptonemal complex central element protein 3; Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes. Chromosome loading appears to require SYCP1. Required for fertility. | 0.528 |
FAM71D | TULP2 | ENSP00000483154 | ENSP00000221399 | Protein FAM71D; Family with sequence similarity 71 member D. | TUB like protein 2; Belongs to the TUB family. | 0.578 |
FAM71D | WBP2NL | ENSP00000483154 | ENSP00000332983 | Protein FAM71D; Family with sequence similarity 71 member D. | Postacrosomal sheath WW domain-binding protein; May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization. | 0.578 |
MS4A5 | FAM71D | ENSP00000300190 | ENSP00000483154 | Membrane-spanning 4-domains subfamily A member 5; May be involved in signal transduction as a component of a multimeric receptor complex. | Protein FAM71D; Family with sequence similarity 71 member D. | 0.579 |
OR51I2 | FAM71D | ENSP00000493016 | ENSP00000483154 | Olfactory receptor 51I2; Odorant receptor; Belongs to the G-protein coupled receptor 1 family. | Protein FAM71D; Family with sequence similarity 71 member D. | 0.559 |
RNF17 | FAM71D | ENSP00000255324 | ENSP00000483154 | RING finger protein 17; Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity). | Protein FAM71D; Family with sequence similarity 71 member D. | 0.545 |
RNF17 | ROPN1L | ENSP00000255324 | ENSP00000421405 | RING finger protein 17; Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity). | Ropporin-1-like protein; Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation. | 0.531 |
RNF17 | SLC9B1 | ENSP00000255324 | ENSP00000296422 | RING finger protein 17; Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity). | Sodium/hydrogen exchanger 9B1; Sperm-specific Na(+)/H(+) exchanger involved in intracellular pH regulation of spermatozoa. Involved in sperm motility and fertility. Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. | 0.467 |
RNF17 | SPATA16 | ENSP00000255324 | ENSP00000341765 | RING finger protein 17; Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity). | Spermatogenesis-associated protein 16; Involved in the formation of sperm acrosome, which implicated its potential role in spermatogenesis and sperm-egg fusion. | 0.520 |
RNF17 | TULP2 | ENSP00000255324 | ENSP00000221399 | RING finger protein 17; Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity). | TUB like protein 2; Belongs to the TUB family. | 0.460 |
RNF17 | WBP2NL | ENSP00000255324 | ENSP00000332983 | RING finger protein 17; Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity). | Postacrosomal sheath WW domain-binding protein; May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization. | 0.461 |
ROPN1L | FAM71D | ENSP00000421405 | ENSP00000483154 | Ropporin-1-like protein; Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation. | Protein FAM71D; Family with sequence similarity 71 member D. | 0.564 |
ROPN1L | RNF17 | ENSP00000421405 | ENSP00000255324 | Ropporin-1-like protein; Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation. | RING finger protein 17; Seems to be involved in regulation of transcriptional activity of MYC. In vitro, inhibits DNA-binding activity of Mad-MAX heterodimers. Can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. May be involved in spermiogenesis (By similarity). | 0.531 |