node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABHD18 | KIAA0408 | ENSP00000496010 | ENSP00000435150 | Protein ABHD18; Abhydrolase domain containing 18; Belongs to the AB hydrolase superfamily. | Uncharacterized protein KIAA0408; KIAA0408. | 0.460 |
ABI3 | KIAA0408 | ENSP00000225941 | ENSP00000435150 | ABI gene family member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility; Belongs to the ABI family. | Uncharacterized protein KIAA0408; KIAA0408. | 0.717 |
C6orf58 | KIAA0408 | ENSP00000328069 | ENSP00000435150 | Protein LEG1 homolog; May be involved in early liver development. | Uncharacterized protein KIAA0408; KIAA0408. | 0.461 |
C6orf58 | MMACHC | ENSP00000328069 | ENSP00000383840 | Protein LEG1 homolog; May be involved in early liver development. | Methylmalonic aciduria and homocystinuria type C protein; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione-dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and oth [...] | 0.438 |
C6orf58 | SOGA3 | ENSP00000328069 | ENSP00000434570 | Protein LEG1 homolog; May be involved in early liver development. | Protein SOGA3; SOGA family member 3. | 0.637 |
KIAA0408 | ABHD18 | ENSP00000435150 | ENSP00000496010 | Uncharacterized protein KIAA0408; KIAA0408. | Protein ABHD18; Abhydrolase domain containing 18; Belongs to the AB hydrolase superfamily. | 0.460 |
KIAA0408 | ABI3 | ENSP00000435150 | ENSP00000225941 | Uncharacterized protein KIAA0408; KIAA0408. | ABI gene family member 3; May inhibit tumor metastasis (By similarity). In vitro, reduces cell motility; Belongs to the ABI family. | 0.717 |
KIAA0408 | C6orf58 | ENSP00000435150 | ENSP00000328069 | Uncharacterized protein KIAA0408; KIAA0408. | Protein LEG1 homolog; May be involved in early liver development. | 0.461 |
KIAA0408 | MANEAL | ENSP00000435150 | ENSP00000362136 | Uncharacterized protein KIAA0408; KIAA0408. | Glycoprotein endo-alpha-1,2-mannosidase-like protein; Mannosidase endo-alpha like; Belongs to the glycosyl hydrolase 99 family. | 0.453 |
KIAA0408 | MMACHC | ENSP00000435150 | ENSP00000383840 | Uncharacterized protein KIAA0408; KIAA0408. | Methylmalonic aciduria and homocystinuria type C protein; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione-dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and oth [...] | 0.474 |
KIAA0408 | PHF1 | ENSP00000435150 | ENSP00000363640 | Uncharacterized protein KIAA0408; KIAA0408. | PHD finger protein 1; Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing [...] | 0.591 |
KIAA0408 | POLR3C | ENSP00000435150 | ENSP00000334564 | Uncharacterized protein KIAA0408; KIAA0408. | DNA-directed RNA polymerase III subunit RPC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during i [...] | 0.591 |
KIAA0408 | SOGA3 | ENSP00000435150 | ENSP00000434570 | Uncharacterized protein KIAA0408; KIAA0408. | Protein SOGA3; SOGA family member 3. | 0.715 |
KIAA0408 | ZNF491 | ENSP00000435150 | ENSP00000313443 | Uncharacterized protein KIAA0408; KIAA0408. | Zinc finger protein 491; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.476 |
KIAA0408 | ZNF628 | ENSP00000435150 | ENSP00000469591 | Uncharacterized protein KIAA0408; KIAA0408. | Zinc finger protein 628; Transcription activator. Binds DNA on GT-box consensus sequence 5'-TTGGTT-3' (By similarity). | 0.575 |
MANEAL | KIAA0408 | ENSP00000362136 | ENSP00000435150 | Glycoprotein endo-alpha-1,2-mannosidase-like protein; Mannosidase endo-alpha like; Belongs to the glycosyl hydrolase 99 family. | Uncharacterized protein KIAA0408; KIAA0408. | 0.453 |
MMACHC | C6orf58 | ENSP00000383840 | ENSP00000328069 | Methylmalonic aciduria and homocystinuria type C protein; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione-dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and oth [...] | Protein LEG1 homolog; May be involved in early liver development. | 0.438 |
MMACHC | KIAA0408 | ENSP00000383840 | ENSP00000435150 | Methylmalonic aciduria and homocystinuria type C protein; Catalyzes the reductive dealkylation of cyanocobalamin to cob(II)alamin, using FAD or FMN as cofactor and NADPH as cosubstrate. Can also catalyze the glutathione-dependent reductive demethylation of methylcobalamin, and, with much lower efficiency, the glutathione-dependent reductive demethylation of adenosylcobalamin. Under anaerobic conditions cob(I)alamin is the first product; it is highly reactive and is converted to aquocob(II)alamin in the presence of oxygen. Binds cyanocobalamin, adenosylcobalamin, methylcobalamin and oth [...] | Uncharacterized protein KIAA0408; KIAA0408. | 0.474 |
PHF1 | KIAA0408 | ENSP00000363640 | ENSP00000435150 | PHD finger protein 1; Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing [...] | Uncharacterized protein KIAA0408; KIAA0408. | 0.591 |
POLR3C | KIAA0408 | ENSP00000334564 | ENSP00000435150 | DNA-directed RNA polymerase III subunit RPC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during i [...] | Uncharacterized protein KIAA0408; KIAA0408. | 0.591 |