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HSD17B8 protein (Canis lupus) - STRING interaction network
"HSD17B8" - Estradiol 17-beta-dehydrogenase 8 in Canis lupus
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
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HSD17B8Estradiol 17-beta-dehydrogenase 8; NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol. Has very low activity towards testosterone. The heterotetramer with CBR4 has NADH-dependent 3- ketoacyl-acyl carrier protein reductase activity, and thereby plays a role in mitochondrial fatty acid biosynthesis. Within the heterotetramer, HSD17B8 binds NADH; CBR4 binds NADPD (259 aa)    
Predicted Functional Partners:
CBR4
Carbonyl reductase 4 (237 aa)
   
0.988
HSD3B2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase; 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids (By similarity) (377 aa)
     
  0.912
CYP17A1
Cytochrome P450, family 17, subfamily A, polypeptide 1 (493 aa)
       
  0.912
CYP19A1
Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens (503 aa)
       
  0.907
LOC491379
Uncharacterized protein (326 aa)
     
 
  0.906
LOC482711
Uncharacterized protein (326 aa)
     
 
  0.906
CYP11B2
Uncharacterized protein; Belongs to the cytochrome P450 family (503 aa)
       
  0.903
SULT1E1
Sulfotransferase family 1E, estrogen-preferring, member 1; Belongs to the sulfotransferase 1 family (295 aa)
         
  0.902
SRD5A1
Steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) (255 aa)
         
  0.901
CYP1B1
Canis lupus familiaris cytochrome P450, family 1, subfamily B, polypeptide 1 (CYP1B1), mRNA (543 aa)
       
    0.901
Your Current Organism:
Canis lupus
NCBI taxonomy Id: 9612
Other names: C. lupus, Canis familiaris, Canis lupus, gray wolf, grey wolf
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