STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AQP1Aquaporin-1; Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. (373 aa)    
Predicted Functional Partners:
GYPA
Glycophorin-A; Glycophorin A is the major intrinsic membrane sialoglycoprotein of the erythrocyte. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane (By similarity).
   
 0.947
AQP9
Aquaporin 9; Belongs to the MIP/aquaporin (TC 1.A.8) family.
  
  
0.821
RHAG
Ammonium transporter Rh type A; May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. Involved in ammonia transport across the erythrocyte membrane. Seems to act in monovalent cation transport.
   
 
 0.798
MDFI
MyoD family inhibitor.
    
   0.774
AQP11
Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.
     
 0.773
SLC4A1
Anion exchange protein.
   
 0.768
EPB42
Erythrocyte membrane protein band 4.2.
   
  0.719
LCN8
Lipocalin 15; Belongs to the calycin superfamily. Lipocalin family.
      
 0.692
ADCYAP1R1
ADCYAP receptor type I; Belongs to the G-protein coupled receptor 2 family.
   
  
 0.690
AQP8
Aquaporin 8; Belongs to the MIP/aquaporin (TC 1.A.8) family.
  
  
0.688
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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