STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLEKPleckstrin; Major protein kinase C substrate of platelets (351 aa)    
Predicted Functional Partners:
LCP2
Lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
   
  
 0.785
ITGB2
Integrin beta-2 isoform x1; Integrin beta
   
  
 0.753
PTPRC
Receptor-type tyrosine-protein phosphatase c isoform x1; Protein tyrosine phosphatase, receptor type, C
   
  
 0.721
MTOR
Serine/threonine-protein kinase mtor isoform x1; Serine/threonine-protein kinase mTOR; Mechanistic target of rapamycin (serine/threonine kinase)
   
  
 0.720
FYB
Fyn binding protein 1; FYN binding protein
   
  
 0.703
MCF2
MCF.2 cell line derived transforming sequence
      
 0.693
CYTH4
Cytohesin-4; Cytohesin 4
   
  
0.681
SPI1
Transcription factor pu.1 isoform x1; Spi-1 proto-oncogene
   
  
 0.681
RGS18
Regulator of G-protein signaling 18
   
  
 0.679
BTK
Bruton agammaglobulinemia tyrosine kinase
   
  
 0.674
Your Current Organism:
Canis lupus
NCBI taxonomy Id: 9612
Other names: C. lupus, Canis familiaris, gray wolf, grey wolf
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