STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TSPAN12Tetraspanin. (305 aa)    
Predicted Functional Partners:
FZD4
Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.
   
 
 0.885
NDP
Norrin cystine knot growth factor NDP.
   
 
 0.868
LRP5
Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.
      
 0.783
ZNF408
Zinc finger protein 408.
      
 0.777
RECK
Reversion inducing cysteine rich protein with kazal motifs.
   
  
 0.769
TSPAN17
Tetraspanin.
   
  
 0.678
LGR4
Leucine rich repeat containing G protein-coupled receptor 4.
   
  
 0.589
TSPAN31
Tetraspanin 31; Belongs to the tetraspanin (TM4SF) family.
   
  
 0.571
ADGRA2
Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family.
      
 0.570
FAM49A
Family with sequence similarity 49 member A.
      
 0.569
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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