node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCNA2 | CCND1 | ENSCAFP00000006129 | ENSCAFP00000061968 | Cyclin A2; Belongs to the cyclin family. | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | 0.545 |
CCNA2 | CDK4 | ENSCAFP00000006129 | ENSCAFP00000000402 | Cyclin A2; Belongs to the cyclin family. | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | 0.979 |
CCNA2 | CDK6 | ENSCAFP00000006129 | ENSCAFP00000002945 | Cyclin A2; Belongs to the cyclin family. | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. | 0.995 |
CCNA2 | E2F2 | ENSCAFP00000006129 | ENSCAFP00000019556 | Cyclin A2; Belongs to the cyclin family. | E2F transcription factor 2. | 0.955 |
CCNA2 | E2F3 | ENSCAFP00000006129 | ENSCAFP00000041377 | Cyclin A2; Belongs to the cyclin family. | E2F transcription factor 3. | 0.948 |
CCNA2 | E2F4 | ENSCAFP00000006129 | ENSCAFP00000037675 | Cyclin A2; Belongs to the cyclin family. | E2F transcription factor 4. | 0.786 |
CCNA2 | RB1 | ENSCAFP00000006129 | ENSCAFP00000057502 | Cyclin A2; Belongs to the cyclin family. | RB transcriptional corepressor 1. | 0.976 |
CCNA2 | TFDP1 | ENSCAFP00000006129 | ENSCAFP00000063174 | Cyclin A2; Belongs to the cyclin family. | Transcription factor. | 0.613 |
CCNA2 | TFDP2 | ENSCAFP00000006129 | ENSCAFP00000044192 | Cyclin A2; Belongs to the cyclin family. | Transcription factor Dp-2. | 0.581 |
CCND1 | CCNA2 | ENSCAFP00000061968 | ENSCAFP00000006129 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | Cyclin A2; Belongs to the cyclin family. | 0.545 |
CCND1 | CDK4 | ENSCAFP00000061968 | ENSCAFP00000000402 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | 0.999 |
CCND1 | CDK6 | ENSCAFP00000061968 | ENSCAFP00000002945 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. | 0.999 |
CCND1 | E2F2 | ENSCAFP00000061968 | ENSCAFP00000019556 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | E2F transcription factor 2. | 0.477 |
CCND1 | E2F3 | ENSCAFP00000061968 | ENSCAFP00000041377 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | E2F transcription factor 3. | 0.602 |
CCND1 | HDAC1 | ENSCAFP00000061968 | ENSCAFP00000036819 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. | 0.521 |
CCND1 | RB1 | ENSCAFP00000061968 | ENSCAFP00000057502 | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | RB transcriptional corepressor 1. | 0.987 |
CDK4 | CCNA2 | ENSCAFP00000000402 | ENSCAFP00000006129 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | Cyclin A2; Belongs to the cyclin family. | 0.979 |
CDK4 | CCND1 | ENSCAFP00000000402 | ENSCAFP00000061968 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | G1/S-specific cyclin-D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. A [...] | 0.999 |
CDK4 | CDK6 | ENSCAFP00000000402 | ENSCAFP00000002945 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. | 0.976 |
CDK4 | E2F2 | ENSCAFP00000000402 | ENSCAFP00000019556 | Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. | E2F transcription factor 2. | 0.709 |