node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EGR1 | EGR2 | ENSCAFP00000001811 | ENSCAFP00000019211 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | Early growth response 2. | 0.833 |
EGR1 | EGR3 | ENSCAFP00000001811 | ENSCAFP00000013621 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | Early growth response 3. | 0.505 |
EGR1 | FOSB | ENSCAFP00000001811 | ENSCAFP00000051752 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | Protein fosB; FosB interacts with Jun proteins enhancing their DNA binding activity. | 0.907 |
EGR1 | FOSL2 | ENSCAFP00000001811 | ENSCAFP00000063542 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | FOS like 2, AP-1 transcription factor subunit. | 0.493 |
EGR1 | JUNB | ENSCAFP00000001811 | ENSCAFP00000036269 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | JunB proto-oncogene, AP-1 transcription factor subunit. | 0.684 |
EGR1 | JUND | ENSCAFP00000001811 | ENSCAFP00000031140 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | JunD proto-oncogene, AP-1 transcription factor subunit. | 0.546 |
EGR1 | NR4A1 | ENSCAFP00000001811 | ENSCAFP00000062914 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | Nuclear receptor subfamily 4 group A member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). | 0.783 |
EGR1 | NR4A2 | ENSCAFP00000001811 | ENSCAFP00000013553 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | Nuclear receptor subfamily 4 group A member 2. | 0.566 |
EGR2 | EGR1 | ENSCAFP00000019211 | ENSCAFP00000001811 | Early growth response 2. | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | 0.833 |
EGR2 | EGR3 | ENSCAFP00000019211 | ENSCAFP00000013621 | Early growth response 2. | Early growth response 3. | 0.970 |
EGR2 | FOSB | ENSCAFP00000019211 | ENSCAFP00000051752 | Early growth response 2. | Protein fosB; FosB interacts with Jun proteins enhancing their DNA binding activity. | 0.755 |
EGR2 | FOSL2 | ENSCAFP00000019211 | ENSCAFP00000063542 | Early growth response 2. | FOS like 2, AP-1 transcription factor subunit. | 0.406 |
EGR2 | NR4A1 | ENSCAFP00000019211 | ENSCAFP00000062914 | Early growth response 2. | Nuclear receptor subfamily 4 group A member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). | 0.580 |
EGR2 | NR4A2 | ENSCAFP00000019211 | ENSCAFP00000013553 | Early growth response 2. | Nuclear receptor subfamily 4 group A member 2. | 0.469 |
EGR3 | EGR1 | ENSCAFP00000013621 | ENSCAFP00000001811 | Early growth response 3. | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | 0.505 |
EGR3 | EGR2 | ENSCAFP00000013621 | ENSCAFP00000019211 | Early growth response 3. | Early growth response 2. | 0.970 |
EGR3 | FOSB | ENSCAFP00000013621 | ENSCAFP00000051752 | Early growth response 3. | Protein fosB; FosB interacts with Jun proteins enhancing their DNA binding activity. | 0.699 |
EGR3 | FOSL2 | ENSCAFP00000013621 | ENSCAFP00000063542 | Early growth response 3. | FOS like 2, AP-1 transcription factor subunit. | 0.441 |
EGR3 | JUNB | ENSCAFP00000013621 | ENSCAFP00000036269 | Early growth response 3. | JunB proto-oncogene, AP-1 transcription factor subunit. | 0.416 |
EGR3 | NR4A1 | ENSCAFP00000013621 | ENSCAFP00000062914 | Early growth response 3. | Nuclear receptor subfamily 4 group A member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). | 0.559 |