STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MEGF8Multiple EGF like domains 8. (439 aa)    
Predicted Functional Partners:
SMO
Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.
   
 
 0.937
CARD19
Caspase recruitment domain family member 19.
      
 0.810
MGRN1
Mahogunin ring finger 1.
   
 
 0.797
ABTB1
Ankyrin repeat and BTB domain containing 1.
    
 
 0.792
RBM23
RNA binding motif protein 23.
      
 0.738
DCLK3
Tetratricopeptide repeat and ankyrin repeat containing 1.
      
 0.737
SLC9C2
Solute carrier family 9 member C2 (putative).
      
 0.727
SLC22A12
MFS domain-containing protein.
   
  
 0.725
RNF157
Ring finger protein 157.
   
 
 0.724
MOSMO
Modulator of smoothened.
      
 0.710
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.