node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKT1 | AKT2 | ENSCAFP00000027133 | ENSCAFP00000008032 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | AKT serine/threonine kinase 2. | 0.906 |
AKT1 | AKT3 | ENSCAFP00000027133 | ENSCAFP00000023241 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.902 |
AKT1 | CTNNB1 | ENSCAFP00000027133 | ENSCAFP00000007783 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | 0.423 |
AKT1 | GSK3A | ENSCAFP00000027133 | ENSCAFP00000007287 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.950 |
AKT1 | GSK3B | ENSCAFP00000027133 | ENSCAFP00000034412 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. | 0.951 |
AKT1 | TRAF6 | ENSCAFP00000027133 | ENSCAFP00000010159 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.473 |
AKT2 | AKT1 | ENSCAFP00000008032 | ENSCAFP00000027133 | AKT serine/threonine kinase 2. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.906 |
AKT2 | AKT3 | ENSCAFP00000008032 | ENSCAFP00000023241 | AKT serine/threonine kinase 2. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.904 |
AKT2 | CTNNB1 | ENSCAFP00000008032 | ENSCAFP00000007783 | AKT serine/threonine kinase 2. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | 0.401 |
AKT2 | GSK3A | ENSCAFP00000008032 | ENSCAFP00000007287 | AKT serine/threonine kinase 2. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.949 |
AKT2 | GSK3B | ENSCAFP00000008032 | ENSCAFP00000034412 | AKT serine/threonine kinase 2. | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. | 0.949 |
AKT2 | TRAF6 | ENSCAFP00000008032 | ENSCAFP00000010159 | AKT serine/threonine kinase 2. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.428 |
AKT3 | AKT1 | ENSCAFP00000023241 | ENSCAFP00000027133 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.902 |
AKT3 | AKT2 | ENSCAFP00000023241 | ENSCAFP00000008032 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | AKT serine/threonine kinase 2. | 0.904 |
AKT3 | CTNNB1 | ENSCAFP00000023241 | ENSCAFP00000007783 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] | 0.464 |
AKT3 | GSK3A | ENSCAFP00000023241 | ENSCAFP00000007287 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. | 0.945 |
AKT3 | GSK3B | ENSCAFP00000023241 | ENSCAFP00000034412 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. | 0.947 |
AKT3 | TRAF6 | ENSCAFP00000023241 | ENSCAFP00000010159 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.473 |
AXIN1 | AXIN2 | ENSCAFP00000054479 | ENSCAFP00000016564 | Axin 1. | Axin 2. | 0.847 |
AXIN1 | BTRC | ENSCAFP00000054479 | ENSCAFP00000014526 | Axin 1. | Beta-transducin repeat containing E3 ubiquitin protein ligase. | 0.765 |