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PAK1 protein (Canis lupus) - STRING interaction network
"PAK1" - P21 protein in Canis lupus
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
PAK1P21 protein (Cdc42/Rac)-activated kinase 1 (544 aa)    
Predicted Functional Partners:
CDC42
Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration. Required for DOCK [...] (191 aa)
     
  0.994
ENSCAFG00000012631
Uncharacterized protein; Belongs to the small GTPase superfamily. Rho family (179 aa)
     
  0.987
ARHGEF7
Rho guanine nucleotide exchange factor (GEF) 7 (723 aa)
     
  0.986
FLNA
Filamin A, alpha (2646 aa)
     
  0.984
RAC2
Ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); Belongs to the small GTPase superfamily. Rho family (192 aa)
     
  0.976
RAC1
Ras-related C3 botulinum toxin substrate 1; Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in macrophages. Essential for the SPATA13-mediated [...] (211 aa)
     
  0.962
NF2
Neurofibromin 2 (merlin) (596 aa)
     
  0.956
NCK1
NCK adaptor protein 1 (377 aa)
     
  0.954
GIT1
GIT ArfGAP 1; G protein-coupled receptor kinase interacting ArfGAP 1 (753 aa)
     
  0.952
NCK2
NCK adaptor protein 2 (380 aa)
     
  0.950
Your Current Organism:
Canis lupus
NCBI taxonomy Id: 9612
Other names: C. lupus, Canis familiaris, Canis lupus, gray wolf, grey wolf
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