node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABRAXAS1 | ATM | ENSCAFP00000013419 | ENSCAFP00000035996 | Abraxas 1, BRCA1 A complex subunit. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.601 |
ABRAXAS1 | BABAM1 | ENSCAFP00000013419 | ENSCAFP00000022754 | Abraxas 1, BRCA1 A complex subunit. | BRISC and BRCA1 A complex member 1. | 0.998 |
ABRAXAS1 | BABAM2 | ENSCAFP00000013419 | ENSCAFP00000053919 | Abraxas 1, BRCA1 A complex subunit. | BRISC and BRCA1 A complex member 2. | 0.995 |
ABRAXAS1 | BARD1 | ENSCAFP00000013419 | ENSCAFP00000021054 | Abraxas 1, BRCA1 A complex subunit. | BRCA1 associated RING domain 1. | 0.985 |
ABRAXAS1 | BRCA1 | ENSCAFP00000013419 | ENSCAFP00000048759 | Abraxas 1, BRCA1 A complex subunit. | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.997 |
ABRAXAS1 | BRCC3 | ENSCAFP00000013419 | ENSCAFP00000039536 | Abraxas 1, BRCA1 A complex subunit. | BRCA1/BRCA2-containing complex subunit 3. | 0.931 |
ABRAXAS1 | ENSCAFP00000046717 | ENSCAFP00000013419 | ENSCAFP00000046717 | Abraxas 1, BRCA1 A complex subunit. | MPN domain-containing protein. | 0.985 |
ABRAXAS1 | HERC2 | ENSCAFP00000013419 | ENSCAFP00000014527 | Abraxas 1, BRCA1 A complex subunit. | HECT and RLD domain containing E3 ubiquitin protein ligase 2. | 0.499 |
ABRAXAS1 | UIMC1 | ENSCAFP00000013419 | ENSCAFP00000024343 | Abraxas 1, BRCA1 A complex subunit. | Ubiquitin interaction motif containing 1. | 0.998 |
ABRAXAS2 | BABAM1 | ENSCAFP00000018773 | ENSCAFP00000022754 | Abraxas 2, BRISC complex subunit. | BRISC and BRCA1 A complex member 1. | 0.987 |
ABRAXAS2 | BABAM2 | ENSCAFP00000018773 | ENSCAFP00000053919 | Abraxas 2, BRISC complex subunit. | BRISC and BRCA1 A complex member 2. | 0.990 |
ABRAXAS2 | BRCC3 | ENSCAFP00000018773 | ENSCAFP00000039536 | Abraxas 2, BRISC complex subunit. | BRCA1/BRCA2-containing complex subunit 3. | 0.899 |
ABRAXAS2 | ENSCAFP00000046717 | ENSCAFP00000018773 | ENSCAFP00000046717 | Abraxas 2, BRISC complex subunit. | MPN domain-containing protein. | 0.978 |
ABRAXAS2 | UIMC1 | ENSCAFP00000018773 | ENSCAFP00000024343 | Abraxas 2, BRISC complex subunit. | Ubiquitin interaction motif containing 1. | 0.412 |
ATM | ABRAXAS1 | ENSCAFP00000035996 | ENSCAFP00000013419 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Abraxas 1, BRCA1 A complex subunit. | 0.601 |
ATM | BABAM1 | ENSCAFP00000035996 | ENSCAFP00000022754 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | BRISC and BRCA1 A complex member 1. | 0.584 |
ATM | BABAM2 | ENSCAFP00000035996 | ENSCAFP00000053919 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | BRISC and BRCA1 A complex member 2. | 0.653 |
ATM | BARD1 | ENSCAFP00000035996 | ENSCAFP00000021054 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | BRCA1 associated RING domain 1. | 0.888 |
ATM | BRCA1 | ENSCAFP00000035996 | ENSCAFP00000048759 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] | 0.996 |
ATM | ENSCAFP00000046717 | ENSCAFP00000035996 | ENSCAFP00000046717 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | MPN domain-containing protein. | 0.572 |