node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B9D2 | SMAD2 | ENSCAFP00000007462 | ENSCAFP00000065569 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | Mothers against decapentaplegic homolog. | 0.965 |
B9D2 | SMAD3 | ENSCAFP00000007462 | ENSCAFP00000025647 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | Mothers against decapentaplegic homolog. | 0.953 |
B9D2 | SMAD4 | ENSCAFP00000007462 | ENSCAFP00000052646 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | Mothers against decapentaplegic homolog. | 0.919 |
B9D2 | SMAD7 | ENSCAFP00000007462 | ENSCAFP00000028133 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | Mothers against decapentaplegic homolog. | 0.925 |
B9D2 | SMURF1 | ENSCAFP00000007462 | ENSCAFP00000022329 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | SMAD specific E3 ubiquitin protein ligase 1. | 0.703 |
B9D2 | SMURF2 | ENSCAFP00000007462 | ENSCAFP00000049702 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | E3 ubiquitin-protein ligase. | 0.443 |
B9D2 | TGFB2 | ENSCAFP00000007462 | ENSCAFP00000015925 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.956 |
B9D2 | TGFB3 | ENSCAFP00000007462 | ENSCAFP00000025188 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | Transforming growth factor beta 3. | 0.938 |
B9D2 | TGFBR1 | ENSCAFP00000007462 | ENSCAFP00000040830 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | 0.999 |
B9D2 | TGFBR2 | ENSCAFP00000007462 | ENSCAFP00000063016 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] | 0.999 |
SMAD2 | B9D2 | ENSCAFP00000065569 | ENSCAFP00000007462 | Mothers against decapentaplegic homolog. | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] | 0.965 |
SMAD2 | SMAD3 | ENSCAFP00000065569 | ENSCAFP00000025647 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog. | 0.990 |
SMAD2 | SMAD4 | ENSCAFP00000065569 | ENSCAFP00000052646 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog. | 0.999 |
SMAD2 | SMAD7 | ENSCAFP00000065569 | ENSCAFP00000028133 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog. | 0.966 |
SMAD2 | SMURF1 | ENSCAFP00000065569 | ENSCAFP00000022329 | Mothers against decapentaplegic homolog. | SMAD specific E3 ubiquitin protein ligase 1. | 0.727 |
SMAD2 | SMURF2 | ENSCAFP00000065569 | ENSCAFP00000049702 | Mothers against decapentaplegic homolog. | E3 ubiquitin-protein ligase. | 0.990 |
SMAD2 | TGFB2 | ENSCAFP00000065569 | ENSCAFP00000015925 | Mothers against decapentaplegic homolog. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.760 |
SMAD2 | TGFB3 | ENSCAFP00000065569 | ENSCAFP00000025188 | Mothers against decapentaplegic homolog. | Transforming growth factor beta 3. | 0.528 |
SMAD2 | TGFBR1 | ENSCAFP00000065569 | ENSCAFP00000040830 | Mothers against decapentaplegic homolog. | Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. | 0.991 |
SMAD2 | TGFBR2 | ENSCAFP00000065569 | ENSCAFP00000063016 | Mothers against decapentaplegic homolog. | TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] | 0.981 |