STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NR1D2Nuclear receptor subfamily 1, group D, member 2 (576 aa)    
Predicted Functional Partners:
MED1
Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors
   
 
 0.906
ARNTL
Aryl hydrocarbon receptor nuclear translocator-like
    
 
 0.852
NR1D1
Nuclear receptor subfamily 1, group D, member 1
   
 
0.850
CRY2
Cryptochrome circadian clock 2
   
 
 0.816
DBP
D-box binding PAR bZIP transcription factor; D site of albumin promoter (albumin D-box) binding protein
   
 
 0.813
CRY1
Cryptochrome circadian clock 1
   
 
 0.768
PER3
Period circadian clock 3
   
 
 0.759
CLOCK
Clock circadian regulator
   
 
 0.747
NPAS2
Neuronal PAS domain protein 2
    
 
 0.724
BHLHE41
Uncharacterized protein; Basic helix-loop-helix family, member e41
   
 
 0.697
Your Current Organism:
Canis lupus
NCBI taxonomy Id: 9612
Other names: C. lupus, Canis familiaris, Canis lupus, gray wolf, grey wolf
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