STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RXFP2Relaxin receptor 2; Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3) (By similarity); Belongs to the G-protein coupled receptor 1 family. (737 aa)    
Predicted Functional Partners:
RLN2
Relaxin A chain; Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals; Belongs to the insulin family.
   
 
 0.985
RXFP3
Relaxin family peptide receptor 3.
   
 
 0.981
RXFP1
Relaxin family peptide receptor 1.
  
0.918
IL27RA
Interleukin 27 receptor subunit alpha.
     
  0.900
RLN3
Relaxin 3.
   
  
 0.793
ADGRL2
Adhesion G protein-coupled receptor L2; Belongs to the G-protein coupled receptor 2 family.
    
 
 0.708
ADGRL1
Adhesion G protein-coupled receptor L1; Belongs to the G-protein coupled receptor 2 family.
    
 
 0.708
ADGRL3
Adhesion G protein-coupled receptor L3; Belongs to the G-protein coupled receptor 2 family.
    
 
 0.708
MSRB3
Methionine sulfoxide reductase B3.
      
 0.654
B3GLCT
Beta 3-glucosyltransferase.
 
    
 0.652
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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