STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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[Homology]
Score
SCN1BSodium channel subunit beta-1; Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-1 can modulate multiple alpha subunit isoforms from brain, skeletal muscle, and heart. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity) (237 aa)    
Predicted Functional Partners:
SCN5A
Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes
   
 0.984
SCN4A
Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes
   
 0.984
SCN1A
Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes
   
 0.981
SCN8A
Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes
   
 0.977
SCN3A
Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes
   
 0.977
SCN2A
Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes
   
 0.977
SCN7A
Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes
   
 0.977
SCN9A
Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes
   
 0.972
SCN11A
Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes
    
 0.967
SCN10A
Sodium channel protein type 10 subunit alpha; Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium- selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms (By similarity); Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.8/SCN10A subfamily
    
 0.962
Your Current Organism:
Canis lupus
NCBI taxonomy Id: 9612
Other names: C. lupus, Canis familiaris, Canis lupus, gray wolf, grey wolf
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