node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AKT1 | AKT2 | ENSCAFP00000027133 | ENSCAFP00000008032 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | AKT serine/threonine kinase 2. | 0.906 |
AKT1 | AKT3 | ENSCAFP00000027133 | ENSCAFP00000023241 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.902 |
AKT1 | MAPK1 | ENSCAFP00000027133 | ENSCAFP00000030998 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.927 |
AKT1 | NR4A1 | ENSCAFP00000027133 | ENSCAFP00000062914 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Nuclear receptor subfamily 4 group A member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). | 0.908 |
AKT2 | AKT1 | ENSCAFP00000008032 | ENSCAFP00000027133 | AKT serine/threonine kinase 2. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.906 |
AKT2 | AKT3 | ENSCAFP00000008032 | ENSCAFP00000023241 | AKT serine/threonine kinase 2. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.904 |
AKT2 | MAPK1 | ENSCAFP00000008032 | ENSCAFP00000030998 | AKT serine/threonine kinase 2. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.916 |
AKT2 | NR4A1 | ENSCAFP00000008032 | ENSCAFP00000062914 | AKT serine/threonine kinase 2. | Nuclear receptor subfamily 4 group A member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). | 0.907 |
AKT3 | AKT1 | ENSCAFP00000023241 | ENSCAFP00000027133 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.902 |
AKT3 | AKT2 | ENSCAFP00000023241 | ENSCAFP00000008032 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | AKT serine/threonine kinase 2. | 0.904 |
AKT3 | MAPK1 | ENSCAFP00000023241 | ENSCAFP00000030998 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.924 |
AKT3 | NR4A1 | ENSCAFP00000023241 | ENSCAFP00000062914 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | Nuclear receptor subfamily 4 group A member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). | 0.908 |
EGR1 | FOSB | ENSCAFP00000001811 | ENSCAFP00000051752 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | Protein fosB; FosB interacts with Jun proteins enhancing their DNA binding activity. | 0.907 |
EGR1 | MAPK1 | ENSCAFP00000001811 | ENSCAFP00000030998 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | 0.922 |
EGR1 | NR4A1 | ENSCAFP00000001811 | ENSCAFP00000062914 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | Nuclear receptor subfamily 4 group A member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). | 0.783 |
FOSB | EGR1 | ENSCAFP00000051752 | ENSCAFP00000001811 | Protein fosB; FosB interacts with Jun proteins enhancing their DNA binding activity. | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | 0.907 |
FOSB | NR4A1 | ENSCAFP00000051752 | ENSCAFP00000062914 | Protein fosB; FosB interacts with Jun proteins enhancing their DNA binding activity. | Nuclear receptor subfamily 4 group A member 1; Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). | 0.739 |
MAPK1 | AKT1 | ENSCAFP00000030998 | ENSCAFP00000027133 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.927 |
MAPK1 | AKT2 | ENSCAFP00000030998 | ENSCAFP00000008032 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | AKT serine/threonine kinase 2. | 0.916 |
MAPK1 | AKT3 | ENSCAFP00000030998 | ENSCAFP00000023241 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. | 0.924 |