STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
POU1F1Pituitary-specific positive transcription factor 1; Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'. (291 aa)    
Predicted Functional Partners:
PROP1
Homeobox protein prophet of Pit-1; Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes; Belongs to the paired homeobox family.
   
 
 0.873
TSHB
Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism.
   
  
 0.817
PRL
Prolactin.
   
  
 0.737
LHX3
LIM homeobox 3.
   
 
 0.727
LHX4
LIM homeobox 4.
   
 
 0.724
GHRHR
Growth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family.
   
  
 0.643
HESX1
HESX homeobox 1.
   
 
 0.613
FSHB
Follicle stimulating hormone beta subunit.
   
  
 0.576
IL17RD
Interleukin 17 receptor D.
   
  
 0.528
GHRH
Growth hormone releasing hormone.
   
  
 0.514
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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