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RAPGEF2 protein (Canis lupus) - STRING interaction network
"RAPGEF2" - Rap guanine nucleotide exchange factor 2 in Canis lupus
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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RAPGEF2Rap guanine nucleotide exchange factor 2; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Acts also as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP or not. Its binding to ligand-activated beta-1 adre [...] (1498 aa)    
Predicted Functional Partners:
HRAS
HRas proto-oncogene, GTPase (248 aa)
     
  0.956
KRAS
KRAS proto-oncogene, GTPase (188 aa)
     
  0.955
NRAS
Uncharacterized protein (189 aa)
     
  0.953
RAP1B
RAP1B, member of RAS oncogene family (184 aa)
     
  0.929
RRAS2
Related RAS viral (r-ras) oncogene homolog 2 (175 aa)
     
  0.910
MRAS
Muscle RAS oncogene homolog (208 aa)
     
  0.907
MAGI2
Membrane associated guanylate kinase, WW and PDZ domain containing 2 (912 aa)
     
  0.903
CTNNB1
Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of the Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activation of Wnt responsive genes. Involved in the regulation of cell adhesion, as compone [...] (781 aa)
       
 
  0.897
MAGI1
Uncharacterized protein (800 aa)
       
  0.864
RRAS
Related RAS viral (r-ras) oncogene homolog (218 aa)
     
  0.848
Your Current Organism:
Canis lupus
NCBI taxonomy Id: 9612
Other names: C. lupus, Canis familiaris, Canis lupus, gray wolf, grey wolf
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