node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACAN | ADAMTS5 | ENSCAFP00000065577 | ENSCAFP00000012608 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | ADAM metallopeptidase with thrombospondin type 1 motif 5. | 0.906 |
ACAN | COL2A1 | ENSCAFP00000065577 | ENSCAFP00000013330 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Collagen type II alpha 1 chain. | 0.953 |
ACAN | COMP | ENSCAFP00000065577 | ENSCAFP00000055935 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Cartilage oligomeric matrix protein. | 0.910 |
ACAN | ITGB1 | ENSCAFP00000065577 | ENSCAFP00000005722 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Integrin beta; Belongs to the integrin beta chain family. | 0.566 |
ACAN | MMP13 | ENSCAFP00000065577 | ENSCAFP00000022174 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | Matrix metallopeptidase 13. | 0.928 |
ACAN | RUNX2 | ENSCAFP00000065577 | ENSCAFP00000042290 | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | RUNX family transcription factor 2. | 0.831 |
ADAMTS5 | ACAN | ENSCAFP00000012608 | ENSCAFP00000065577 | ADAM metallopeptidase with thrombospondin type 1 motif 5. | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.906 |
ADAMTS5 | COL2A1 | ENSCAFP00000012608 | ENSCAFP00000013330 | ADAM metallopeptidase with thrombospondin type 1 motif 5. | Collagen type II alpha 1 chain. | 0.839 |
ADAMTS5 | COMP | ENSCAFP00000012608 | ENSCAFP00000055935 | ADAM metallopeptidase with thrombospondin type 1 motif 5. | Cartilage oligomeric matrix protein. | 0.493 |
ADAMTS5 | MMP13 | ENSCAFP00000012608 | ENSCAFP00000022174 | ADAM metallopeptidase with thrombospondin type 1 motif 5. | Matrix metallopeptidase 13. | 0.902 |
ADAMTS5 | RUNX2 | ENSCAFP00000012608 | ENSCAFP00000042290 | ADAM metallopeptidase with thrombospondin type 1 motif 5. | RUNX family transcription factor 2. | 0.582 |
COL2A1 | ACAN | ENSCAFP00000013330 | ENSCAFP00000065577 | Collagen type II alpha 1 chain. | Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. | 0.953 |
COL2A1 | ADAMTS5 | ENSCAFP00000013330 | ENSCAFP00000012608 | Collagen type II alpha 1 chain. | ADAM metallopeptidase with thrombospondin type 1 motif 5. | 0.839 |
COL2A1 | COMP | ENSCAFP00000013330 | ENSCAFP00000055935 | Collagen type II alpha 1 chain. | Cartilage oligomeric matrix protein. | 0.807 |
COL2A1 | GP6 | ENSCAFP00000013330 | ENSCAFP00000037411 | Collagen type II alpha 1 chain. | Glycoprotein VI platelet. | 0.910 |
COL2A1 | ITGA2 | ENSCAFP00000013330 | ENSCAFP00000027208 | Collagen type II alpha 1 chain. | Integrin subunit alpha 2; Belongs to the integrin alpha chain family. | 0.776 |
COL2A1 | ITGA2B | ENSCAFP00000013330 | ENSCAFP00000053835 | Collagen type II alpha 1 chain. | Integrin subunit alpha 2b; Belongs to the integrin alpha chain family. | 0.773 |
COL2A1 | ITGB1 | ENSCAFP00000013330 | ENSCAFP00000005722 | Collagen type II alpha 1 chain. | Integrin beta; Belongs to the integrin beta chain family. | 0.786 |
COL2A1 | MMP13 | ENSCAFP00000013330 | ENSCAFP00000022174 | Collagen type II alpha 1 chain. | Matrix metallopeptidase 13. | 0.888 |
COL2A1 | PELO | ENSCAFP00000013330 | ENSCAFP00000055731 | Collagen type II alpha 1 chain. | Integrin subunit alpha 1; Belongs to the integrin alpha chain family. | 0.781 |