node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AFDN | CGNL1 | ENSCAFP00000057828 | ENSCAFP00000023957 | Afadin, adherens junction formation factor. | Cingulin like 1. | 0.440 |
AFDN | CLDN1 | ENSCAFP00000057828 | ENSCAFP00000039082 | Afadin, adherens junction formation factor. | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.405 |
AFDN | F11R | ENSCAFP00000057828 | ENSCAFP00000018655 | Afadin, adherens junction formation factor. | F11 receptor. | 0.954 |
AFDN | OCLN | ENSCAFP00000057828 | ENSCAFP00000011546 | Afadin, adherens junction formation factor. | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Interacts with ZO-1. | 0.667 |
AFDN | TJP1 | ENSCAFP00000057828 | ENSCAFP00000065522 | Afadin, adherens junction formation factor. | Tight junction protein ZO-1; TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation. Plays a role in the regulation [...] | 0.983 |
AFDN | TJP2 | ENSCAFP00000057828 | ENSCAFP00000041484 | Afadin, adherens junction formation factor. | Tight junction protein ZO-2; Plays a role in tight junctions and adherens junctions; Belongs to the MAGUK family. | 0.985 |
CGN | F11R | ENSCAFP00000018714 | ENSCAFP00000018655 | Cingulin; Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier; Belongs to the cingulin family. | F11 receptor. | 0.881 |
CGN | OCLN | ENSCAFP00000018714 | ENSCAFP00000011546 | Cingulin; Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier; Belongs to the cingulin family. | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Interacts with ZO-1. | 0.659 |
CGN | TJP1 | ENSCAFP00000018714 | ENSCAFP00000065522 | Cingulin; Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier; Belongs to the cingulin family. | Tight junction protein ZO-1; TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation. Plays a role in the regulation [...] | 0.962 |
CGN | TJP2 | ENSCAFP00000018714 | ENSCAFP00000041484 | Cingulin; Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier; Belongs to the cingulin family. | Tight junction protein ZO-2; Plays a role in tight junctions and adherens junctions; Belongs to the MAGUK family. | 0.702 |
CGNL1 | AFDN | ENSCAFP00000023957 | ENSCAFP00000057828 | Cingulin like 1. | Afadin, adherens junction formation factor. | 0.440 |
CGNL1 | OCLN | ENSCAFP00000023957 | ENSCAFP00000011546 | Cingulin like 1. | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Interacts with ZO-1. | 0.456 |
CGNL1 | TJP1 | ENSCAFP00000023957 | ENSCAFP00000065522 | Cingulin like 1. | Tight junction protein ZO-1; TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation. Plays a role in the regulation [...] | 0.949 |
CLDN1 | AFDN | ENSCAFP00000039082 | ENSCAFP00000057828 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Afadin, adherens junction formation factor. | 0.405 |
CLDN1 | CLDN5 | ENSCAFP00000039082 | ENSCAFP00000045788 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.817 |
CLDN1 | F11R | ENSCAFP00000039082 | ENSCAFP00000018655 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | F11 receptor. | 0.659 |
CLDN1 | OCLN | ENSCAFP00000039082 | ENSCAFP00000011546 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Interacts with ZO-1. | 0.990 |
CLDN1 | TJP1 | ENSCAFP00000039082 | ENSCAFP00000065522 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Tight junction protein ZO-1; TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation. Plays a role in the regulation [...] | 0.968 |
CLDN1 | TJP2 | ENSCAFP00000039082 | ENSCAFP00000041484 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Tight junction protein ZO-2; Plays a role in tight junctions and adherens junctions; Belongs to the MAGUK family. | 0.795 |
CLDN5 | CLDN1 | ENSCAFP00000045788 | ENSCAFP00000039082 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.817 |