node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DKK1 | DKK2 | ENSCAFP00000022864 | ENSCAFP00000016333 | Dickkopf WNT signaling pathway inhibitor 1. | Dickkopf WNT signaling pathway inhibitor 2. | 0.649 |
DKK1 | DKK4 | ENSCAFP00000022864 | ENSCAFP00000008237 | Dickkopf WNT signaling pathway inhibitor 1. | Dickkopf WNT signaling pathway inhibitor 4. | 0.514 |
DKK1 | FZD1 | ENSCAFP00000022864 | ENSCAFP00000002804 | Dickkopf WNT signaling pathway inhibitor 1. | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.508 |
DKK1 | FZD4 | ENSCAFP00000022864 | ENSCAFP00000053452 | Dickkopf WNT signaling pathway inhibitor 1. | Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.563 |
DKK1 | LRP5 | ENSCAFP00000022864 | ENSCAFP00000016050 | Dickkopf WNT signaling pathway inhibitor 1. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.999 |
DKK1 | LRP6 | ENSCAFP00000022864 | ENSCAFP00000060051 | Dickkopf WNT signaling pathway inhibitor 1. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.999 |
DKK1 | SOST | ENSCAFP00000022864 | ENSCAFP00000042377 | Dickkopf WNT signaling pathway inhibitor 1. | Sclerostin. | 0.826 |
DKK1 | WNT1 | ENSCAFP00000022864 | ENSCAFP00000052863 | Dickkopf WNT signaling pathway inhibitor 1. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.661 |
DKK2 | DKK1 | ENSCAFP00000016333 | ENSCAFP00000022864 | Dickkopf WNT signaling pathway inhibitor 2. | Dickkopf WNT signaling pathway inhibitor 1. | 0.649 |
DKK2 | DKK4 | ENSCAFP00000016333 | ENSCAFP00000008237 | Dickkopf WNT signaling pathway inhibitor 2. | Dickkopf WNT signaling pathway inhibitor 4. | 0.905 |
DKK2 | FZD1 | ENSCAFP00000016333 | ENSCAFP00000002804 | Dickkopf WNT signaling pathway inhibitor 2. | Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. | 0.455 |
DKK2 | FZD6 | ENSCAFP00000016333 | ENSCAFP00000000924 | Dickkopf WNT signaling pathway inhibitor 2. | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] | 0.459 |
DKK2 | LRP5 | ENSCAFP00000016333 | ENSCAFP00000016050 | Dickkopf WNT signaling pathway inhibitor 2. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.993 |
DKK2 | LRP6 | ENSCAFP00000016333 | ENSCAFP00000060051 | Dickkopf WNT signaling pathway inhibitor 2. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.991 |
DKK2 | SOST | ENSCAFP00000016333 | ENSCAFP00000042377 | Dickkopf WNT signaling pathway inhibitor 2. | Sclerostin. | 0.705 |
DKK2 | WNT1 | ENSCAFP00000016333 | ENSCAFP00000052863 | Dickkopf WNT signaling pathway inhibitor 2. | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. | 0.803 |
DKK4 | DKK1 | ENSCAFP00000008237 | ENSCAFP00000022864 | Dickkopf WNT signaling pathway inhibitor 4. | Dickkopf WNT signaling pathway inhibitor 1. | 0.514 |
DKK4 | DKK2 | ENSCAFP00000008237 | ENSCAFP00000016333 | Dickkopf WNT signaling pathway inhibitor 4. | Dickkopf WNT signaling pathway inhibitor 2. | 0.905 |
DKK4 | LRP5 | ENSCAFP00000008237 | ENSCAFP00000016050 | Dickkopf WNT signaling pathway inhibitor 4. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.989 |
DKK4 | LRP6 | ENSCAFP00000008237 | ENSCAFP00000060051 | Dickkopf WNT signaling pathway inhibitor 4. | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. | 0.981 |