STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PRG4Proteoglycan 4. (767 aa)    
Predicted Functional Partners:
CSPG4
Chondroitin sulfate proteoglycan 4.
      
 0.638
ACAN
Aggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.
    
 
 0.609
COMP
Cartilage oligomeric matrix protein.
    
 
 0.564
FGFR1OP2
FGFR1 oncogene partner 2.
      
 0.563
OR2K2
Olfactory receptor.
      
 0.519
PDZD9
PDZ domain containing 9.
      
 0.517
FAM222B
Family with sequence similarity 222 member B.
      
 0.517
COL2A1
Collagen type II alpha 1 chain.
   
 
 0.504
FNDC3B
Fibronectin type III domain containing 3B.
    
 
 0.504
LOC482202
Histone H2B; Belongs to the histone H2B family.
      
 0.468
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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