STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DUOX1Dual oxidase 1; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. (1551 aa)    
Predicted Functional Partners:
DUOXA2
Dual oxidase maturation factor 2.
 
 0.987
DUOXA1
Dual oxidase maturation factor 1.
 
 
 
 0.934
CYBA
Cytochrome b-245 alpha chain.
   
 0.830
NOX5
NADPH oxidase 5.
      
0.751
NOXO1
NADPH oxidase organizer 1.
   
 
 0.747
NCF2
Neutrophil cytosolic factor 2.
   
 0.687
NOX4
NADPH oxidase 4.
      
0.683
NOX1
NADPH oxidase 1.
      
0.635
CYBB
Cytochrome b-245 beta chain.
     
0.625
NOXA1
NADPH oxidase activator 1.
   
 
 0.575
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.