STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)    
Predicted Functional Partners:
CBL
Cbl proto-oncogene.
   
 0.994
RAPGEF1
Rap guanine nucleotide exchange factor 1.
   
 0.989
ABL1
Tyrosine-protein kinase.
   
0.979
GAB1
GRB2 associated binding protein 1.
    
 0.978
EGFR
Receptor protein-tyrosine kinase.
    
 0.971
BCAR1
BCAR1 scaffold protein, Cas family member.
    
 0.967
ABL2
Tyrosine-protein kinase.
   
0.963
DOCK1
Dedicator of cytokinesis 1; Belongs to the DOCK family.
    
 0.960
SRC
Tyrosine-protein kinase.
   
0.955
ELMO1
Engulfment and cell motility 1.
   
 0.955
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.