node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
F13B | F2 | ENSCAFP00000054217 | ENSCAFP00000037638 | Coagulation factor XIII B chain. | Coagulation factor II, thrombin; Belongs to the peptidase S1 family. | 0.852 |
F13B | FGA | ENSCAFP00000054217 | ENSCAFP00000036232 | Coagulation factor XIII B chain. | Fibrinogen alpha chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it [...] | 0.892 |
F13B | FGB | ENSCAFP00000054217 | ENSCAFP00000012386 | Coagulation factor XIII B chain. | Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] | 0.720 |
F13B | FGG | ENSCAFP00000054217 | ENSCAFP00000012417 | Coagulation factor XIII B chain. | Fibrinogen gamma chain; Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhan [...] | 0.697 |
F13B | PLG | ENSCAFP00000054217 | ENSCAFP00000001078 | Coagulation factor XIII B chain. | Plasmin heavy chain A; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be m [...] | 0.469 |
F13B | PROC | ENSCAFP00000054217 | ENSCAFP00000064602 | Coagulation factor XIII B chain. | Vitamin K-dependent protein C heavy chain; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family. | 0.749 |
F13B | SERPINA5 | ENSCAFP00000054217 | ENSCAFP00000026080 | Coagulation factor XIII B chain. | Serpin family A member 5; Belongs to the serpin family. | 0.744 |
F13B | SERPINC1 | ENSCAFP00000054217 | ENSCAFP00000021382 | Coagulation factor XIII B chain. | Serpin family C member 1; Belongs to the serpin family. | 0.809 |
F13B | SERPIND1 | ENSCAFP00000054217 | ENSCAFP00000022517 | Coagulation factor XIII B chain. | Serpin family D member 1; Belongs to the serpin family. | 0.881 |
F2 | F13B | ENSCAFP00000037638 | ENSCAFP00000054217 | Coagulation factor II, thrombin; Belongs to the peptidase S1 family. | Coagulation factor XIII B chain. | 0.852 |
F2 | FGA | ENSCAFP00000037638 | ENSCAFP00000036232 | Coagulation factor II, thrombin; Belongs to the peptidase S1 family. | Fibrinogen alpha chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it [...] | 0.986 |
F2 | FGB | ENSCAFP00000037638 | ENSCAFP00000012386 | Coagulation factor II, thrombin; Belongs to the peptidase S1 family. | Fibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] | 0.943 |
F2 | FGG | ENSCAFP00000037638 | ENSCAFP00000012417 | Coagulation factor II, thrombin; Belongs to the peptidase S1 family. | Fibrinogen gamma chain; Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhan [...] | 0.939 |
F2 | PLG | ENSCAFP00000037638 | ENSCAFP00000001078 | Coagulation factor II, thrombin; Belongs to the peptidase S1 family. | Plasmin heavy chain A; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be m [...] | 0.877 |
F2 | PROC | ENSCAFP00000037638 | ENSCAFP00000064602 | Coagulation factor II, thrombin; Belongs to the peptidase S1 family. | Vitamin K-dependent protein C heavy chain; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family. | 0.953 |
F2 | SERPINA5 | ENSCAFP00000037638 | ENSCAFP00000026080 | Coagulation factor II, thrombin; Belongs to the peptidase S1 family. | Serpin family A member 5; Belongs to the serpin family. | 0.705 |
F2 | SERPINC1 | ENSCAFP00000037638 | ENSCAFP00000021382 | Coagulation factor II, thrombin; Belongs to the peptidase S1 family. | Serpin family C member 1; Belongs to the serpin family. | 0.998 |
F2 | SERPIND1 | ENSCAFP00000037638 | ENSCAFP00000022517 | Coagulation factor II, thrombin; Belongs to the peptidase S1 family. | Serpin family D member 1; Belongs to the serpin family. | 0.984 |
F2 | TFPI2 | ENSCAFP00000037638 | ENSCAFP00000003004 | Coagulation factor II, thrombin; Belongs to the peptidase S1 family. | Tissue factor pathway inhibitor. | 0.440 |
FGA | F13B | ENSCAFP00000036232 | ENSCAFP00000054217 | Fibrinogen alpha chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it [...] | Coagulation factor XIII B chain. | 0.892 |