node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CASP3 | CASP7 | ENSCAFP00000011475 | ENSCAFP00000016420 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | Caspase 7; Belongs to the peptidase C14A family. | 0.916 |
CASP3 | CASP9 | ENSCAFP00000011475 | ENSCAFP00000063413 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | Caspase 9; Belongs to the peptidase C14A family. | 0.979 |
CASP3 | PARP1 | ENSCAFP00000011475 | ENSCAFP00000023715 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.991 |
CASP3 | PARP2 | ENSCAFP00000011475 | ENSCAFP00000059353 | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | Poly [ADP-ribose] polymerase. | 0.935 |
CASP7 | CASP3 | ENSCAFP00000016420 | ENSCAFP00000011475 | Caspase 7; Belongs to the peptidase C14A family. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | 0.916 |
CASP7 | CASP9 | ENSCAFP00000016420 | ENSCAFP00000063413 | Caspase 7; Belongs to the peptidase C14A family. | Caspase 9; Belongs to the peptidase C14A family. | 0.949 |
CASP7 | PARP1 | ENSCAFP00000016420 | ENSCAFP00000023715 | Caspase 7; Belongs to the peptidase C14A family. | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.968 |
CASP7 | PARP2 | ENSCAFP00000016420 | ENSCAFP00000059353 | Caspase 7; Belongs to the peptidase C14A family. | Poly [ADP-ribose] polymerase. | 0.929 |
CASP9 | CASP3 | ENSCAFP00000063413 | ENSCAFP00000011475 | Caspase 9; Belongs to the peptidase C14A family. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity); Belongs to the peptidase C14A family. | 0.979 |
CASP9 | CASP7 | ENSCAFP00000063413 | ENSCAFP00000016420 | Caspase 9; Belongs to the peptidase C14A family. | Caspase 7; Belongs to the peptidase C14A family. | 0.949 |
CASP9 | PARP1 | ENSCAFP00000063413 | ENSCAFP00000023715 | Caspase 9; Belongs to the peptidase C14A family. | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.966 |
CASP9 | PARP2 | ENSCAFP00000063413 | ENSCAFP00000059353 | Caspase 9; Belongs to the peptidase C14A family. | Poly [ADP-ribose] polymerase. | 0.932 |
HPF1 | PARG | ENSCAFP00000011386 | ENSCAFP00000010103 | Histone PARylation factor 1. | Poly(ADP-ribose) glycohydrolase. | 0.519 |
HPF1 | PARP1 | ENSCAFP00000011386 | ENSCAFP00000023715 | Histone PARylation factor 1. | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.890 |
HPF1 | PARP2 | ENSCAFP00000011386 | ENSCAFP00000059353 | Histone PARylation factor 1. | Poly [ADP-ribose] polymerase. | 0.876 |
PARG | HPF1 | ENSCAFP00000010103 | ENSCAFP00000011386 | Poly(ADP-ribose) glycohydrolase. | Histone PARylation factor 1. | 0.519 |
PARG | PARP1 | ENSCAFP00000010103 | ENSCAFP00000023715 | Poly(ADP-ribose) glycohydrolase. | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. | 0.957 |
PARG | PARP2 | ENSCAFP00000010103 | ENSCAFP00000059353 | Poly(ADP-ribose) glycohydrolase. | Poly [ADP-ribose] polymerase. | 0.949 |
PARG | POLB | ENSCAFP00000010103 | ENSCAFP00000008250 | Poly(ADP-ribose) glycohydrolase. | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. | 0.620 |
PARG | TIMELESS | ENSCAFP00000010103 | ENSCAFP00000048907 | Poly(ADP-ribose) glycohydrolase. | Timeless circadian regulator. | 0.542 |