STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GUCY2DRetinal guanylyl cyclase 1; Canis lupus familiaris guanylate cyclase 2D, membrane (retina-specific) (GUCY2D), mRNA; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family (1050 aa)    
Predicted Functional Partners:
GUCA1A
Guanylate cyclase activator 1A (retina)
   
 0.995
GUCA1B
Guanylate cyclase activator 1B (retina)
   
 0.952
NCALD
Neurocalcin delta
   
 0.907
GUCA1C
Guanylate cyclase activator 1C
   
 0.892
CNGB1
Cyclic nucleotide gated channel beta 1
   
 
 0.884
PDE6B
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta; This protein participates in processes of transmission and amplification of the visual signal. Necessary for the formation of a functional phosphodiesterase holoenzyme; Belongs to the cyclic nucleotide phosphodiesterase family
   
 0.822
PDE5A
cGMP-specific 3',5'-cyclic phosphodiesterase; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'- GMP. Specifically regulates nitric-oxide-generated cGMP
   
 0.817
LOC485179
Guanylate cyclase
     
0.806
GUCY2F
Guanylate cyclase 2F, retinal
     
0.805
PDE6C
Phosphodiesterase 6C, cGMP-specific, cone, alpha prime
   
 0.803
Your Current Organism:
Canis lupus
NCBI taxonomy Id: 9612
Other names: C. lupus, Canis familiaris, Canis lupus, gray wolf, grey wolf
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