STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CYBACytochrome b-245 alpha chain. (336 aa)    
Predicted Functional Partners:
NOX4
NADPH oxidase 4.
   
 
 0.999
NOX1
NADPH oxidase 1.
   
 0.999
NOXO1
NADPH oxidase organizer 1.
    
 0.999
NCF2
Neutrophil cytosolic factor 2.
   
 0.999
RAC2
Rac family small GTPase 2.
   
 
 0.988
NOX3
Predicted NADPH oxidase-3.
   
 0.976
CYBB
Cytochrome b-245 beta chain.
   
 0.935
NCF4
Neutrophil cytosolic factor 4.
   
 0.862
NOXA1
NADPH oxidase activator 1.
   
 
 0.837
DUOX1
Dual oxidase 1; Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.
   
 0.830
Your Current Organism:
Canis lupus familiaris
NCBI taxonomy Id: 9615
Other names: C. lupus familiaris, Canis canis, Canis domesticus, Canis familiaris, beagle dog, beagle dogs, dog, dogs
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.