node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AR | USP26 | ENSCAFP00000024499 | ENSCAFP00000031408 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | 0.579 |
FBXL14 | JOSD2 | ENSCAFP00000062618 | ENSCAFP00000004402 | F-box and leucine rich repeat protein 14. | Josephin domain containing 2. | 0.525 |
FBXL14 | USP26 | ENSCAFP00000062618 | ENSCAFP00000031408 | F-box and leucine rich repeat protein 14. | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | 0.521 |
FBXO5 | TRAIP | ENSCAFP00000038421 | ENSCAFP00000016303 | F-box protein 5. | TRAF interacting protein. | 0.722 |
FBXO5 | USP26 | ENSCAFP00000038421 | ENSCAFP00000031408 | F-box protein 5. | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | 0.529 |
FRMD7 | HS6ST2 | ENSCAFP00000040728 | ENSCAFP00000027808 | FERM domain containing 7. | Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. | 0.617 |
FRMD7 | RAP2C | ENSCAFP00000040728 | ENSCAFP00000027776 | FERM domain containing 7. | RAP2C, member of RAS oncogene family. | 0.731 |
FRMD7 | USP26 | ENSCAFP00000040728 | ENSCAFP00000031408 | FERM domain containing 7. | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | 0.659 |
HS6ST2 | FRMD7 | ENSCAFP00000027808 | ENSCAFP00000040728 | Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. | FERM domain containing 7. | 0.617 |
HS6ST2 | RAP2C | ENSCAFP00000027808 | ENSCAFP00000027776 | Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. | RAP2C, member of RAS oncogene family. | 0.530 |
HS6ST2 | USP26 | ENSCAFP00000027808 | ENSCAFP00000031408 | Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | 0.526 |
JOSD2 | FBXL14 | ENSCAFP00000004402 | ENSCAFP00000062618 | Josephin domain containing 2. | F-box and leucine rich repeat protein 14. | 0.525 |
JOSD2 | USP26 | ENSCAFP00000004402 | ENSCAFP00000031408 | Josephin domain containing 2. | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | 0.534 |
MED13 | USP26 | ENSCAFP00000026124 | ENSCAFP00000031408 | Mediator of RNA polymerase II transcription subunit 13; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | 0.541 |
RAP2C | FRMD7 | ENSCAFP00000027776 | ENSCAFP00000040728 | RAP2C, member of RAS oncogene family. | FERM domain containing 7. | 0.731 |
RAP2C | HS6ST2 | ENSCAFP00000027776 | ENSCAFP00000027808 | RAP2C, member of RAS oncogene family. | Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. | 0.530 |
RAP2C | USP26 | ENSCAFP00000027776 | ENSCAFP00000031408 | RAP2C, member of RAS oncogene family. | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | 0.563 |
TRAIP | FBXO5 | ENSCAFP00000016303 | ENSCAFP00000038421 | TRAF interacting protein. | F-box protein 5. | 0.722 |
TRAIP | USP26 | ENSCAFP00000016303 | ENSCAFP00000031408 | TRAF interacting protein. | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | 0.566 |
UBA1 | USP26 | ENSCAFP00000059274 | ENSCAFP00000031408 | Ubiquitin like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family. | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. | 0.521 |