node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CCL19 | CCL2 | ENSCAFP00000002873 | ENSCAFP00000027107 | C-C motif chemokine. | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | 0.715 |
CCL19 | CCL4 | ENSCAFP00000002873 | ENSCAFP00000045688 | C-C motif chemokine. | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | 0.758 |
CCL19 | CCR6 | ENSCAFP00000002873 | ENSCAFP00000044791 | C-C motif chemokine. | C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. | 0.894 |
CCL19 | CXCL10 | ENSCAFP00000002873 | ENSCAFP00000032015 | C-C motif chemokine. | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | 0.929 |
CCL19 | CXCL11 | ENSCAFP00000002873 | ENSCAFP00000055313 | C-C motif chemokine. | C-X-C motif chemokine ligand 11. | 0.782 |
CCL19 | CXCL12 | ENSCAFP00000002873 | ENSCAFP00000037130 | C-C motif chemokine. | SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. | 0.957 |
CCL19 | CXCL13 | ENSCAFP00000002873 | ENSCAFP00000034611 | C-C motif chemokine. | C-X-C motif chemokine. | 0.979 |
CCL19 | CXCR3 | ENSCAFP00000002873 | ENSCAFP00000025254 | C-C motif chemokine. | C-X-C chemokine receptor type 3; Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response (By similarity). | 0.832 |
CCL19 | CXCR5 | ENSCAFP00000002873 | ENSCAFP00000018310 | C-C motif chemokine. | C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. | 0.962 |
CCL2 | CCL19 | ENSCAFP00000027107 | ENSCAFP00000002873 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | C-C motif chemokine. | 0.715 |
CCL2 | CCL4 | ENSCAFP00000027107 | ENSCAFP00000045688 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | C-C motif chemokine 4; Monokine with inflammatory and chemokinetic properties. | 0.986 |
CCL2 | CCR6 | ENSCAFP00000027107 | ENSCAFP00000044791 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. | 0.877 |
CCL2 | CXCL10 | ENSCAFP00000027107 | ENSCAFP00000032015 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | 0.934 |
CCL2 | CXCL11 | ENSCAFP00000027107 | ENSCAFP00000055313 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | C-X-C motif chemokine ligand 11. | 0.647 |
CCL2 | CXCL12 | ENSCAFP00000027107 | ENSCAFP00000037130 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. | 0.836 |
CCL2 | CXCL13 | ENSCAFP00000027107 | ENSCAFP00000034611 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | C-X-C motif chemokine. | 0.978 |
CCL2 | CXCR3 | ENSCAFP00000027107 | ENSCAFP00000025254 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | C-X-C chemokine receptor type 3; Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response (By similarity). | 0.941 |
CCL2 | CXCR5 | ENSCAFP00000027107 | ENSCAFP00000018310 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] | C-X-C motif chemokine receptor 5; Belongs to the G-protein coupled receptor 1 family. | 0.770 |
CCL28 | CCR6 | ENSCAFP00000031374 | ENSCAFP00000044791 | C-C motif chemokine 28; Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner (By similarity); Belongs to the intercrine beta (chemokine CC) family. | C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. | 0.652 |
CCL28 | CXCL10 | ENSCAFP00000031374 | ENSCAFP00000032015 | C-C motif chemokine 28; Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner (By similarity); Belongs to the intercrine beta (chemokine CC) family. | C-X-C motif chemokine 10; Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (By similarity). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pat [...] | 0.937 |