node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD44 | MMP9 | ENSCAFP00000050335 | ENSCAFP00000035167 | CD44 antigen. | Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). | 0.985 |
CD44 | SDC1 | ENSCAFP00000050335 | ENSCAFP00000059447 | CD44 antigen. | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. | 0.594 |
CD44 | SRC | ENSCAFP00000050335 | ENSCAFP00000044994 | CD44 antigen. | Tyrosine-protein kinase. | 0.760 |
CD44 | THBS1 | ENSCAFP00000050335 | ENSCAFP00000012843 | CD44 antigen. | Thrombospondin 1. | 0.617 |
CD44 | TIMP1 | ENSCAFP00000050335 | ENSCAFP00000062428 | CD44 antigen. | Metalloproteinase inhibitor 1. | 0.552 |
EDN1 | MMP9 | ENSCAFP00000014389 | ENSCAFP00000035167 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). | 0.958 |
EDN1 | SRC | ENSCAFP00000014389 | ENSCAFP00000044994 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Tyrosine-protein kinase. | 0.438 |
EDN1 | THBS1 | ENSCAFP00000014389 | ENSCAFP00000012843 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Thrombospondin 1. | 0.604 |
EDN1 | TIMP1 | ENSCAFP00000014389 | ENSCAFP00000062428 | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | Metalloproteinase inhibitor 1. | 0.416 |
MMP1 | MMP9 | ENSCAFP00000038708 | ENSCAFP00000035167 | Matrix metallopeptidase 1. | Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). | 0.952 |
MMP1 | TIMP1 | ENSCAFP00000038708 | ENSCAFP00000062428 | Matrix metallopeptidase 1. | Metalloproteinase inhibitor 1. | 0.953 |
MMP1 | TIMP2 | ENSCAFP00000038708 | ENSCAFP00000035219 | Matrix metallopeptidase 1. | Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family. | 0.814 |
MMP1 | TIMP3 | ENSCAFP00000038708 | ENSCAFP00000040576 | Matrix metallopeptidase 1. | TIMP metallopeptidase inhibitor 3. | 0.668 |
MMP9 | CD44 | ENSCAFP00000035167 | ENSCAFP00000050335 | Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). | CD44 antigen. | 0.985 |
MMP9 | EDN1 | ENSCAFP00000035167 | ENSCAFP00000014389 | Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). | Big endothelin-1; Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Belongs to the endothelin/sarafotoxin family. | 0.958 |
MMP9 | MMP1 | ENSCAFP00000035167 | ENSCAFP00000038708 | Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). | Matrix metallopeptidase 1. | 0.952 |
MMP9 | SDC1 | ENSCAFP00000035167 | ENSCAFP00000059447 | Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). | Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. | 0.956 |
MMP9 | SRC | ENSCAFP00000035167 | ENSCAFP00000044994 | Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). | Tyrosine-protein kinase. | 0.971 |
MMP9 | THBS1 | ENSCAFP00000035167 | ENSCAFP00000012843 | Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). | Thrombospondin 1. | 0.976 |
MMP9 | TIMP1 | ENSCAFP00000035167 | ENSCAFP00000062428 | Matrix metalloproteinase-9; Could play a role in bone osteoclastic resorption. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (By similarity). | Metalloproteinase inhibitor 1. | 0.973 |